Phenotypes Associated with This Genotype

Genotype
MGI:3042042

• Allelic Composition: Mapk7^tm1Jdl/Mapk7^tm1Jdl; Tg(Tek-cre)12Flv/0
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:89215 )

• fetuses died between E9.5 and E10.5 exhibiting cardiovascular defects

cardiovascular system

abnormal vitelline vasculature morphology ( J:89215 )

• abnormal yolk sac blood vessels, appearing loose and fragile

trabecula carnea hypoplasia ( J:89215 )

• reduced trabeculation in the ventricular chamber

abnormal heart development ( J:89215 )

• impaired myocardium development when compared to controls

abnormal endocardium morphology ( J:89215 )

• impaired endocardium development with the abnormally shaped endothelial cells irregularly aligning with the myocardium

embryo

abnormal vitelline vasculature morphology ( J:89215 )

• abnormal yolk sac blood vessels, appearing loose and fragile

muscle

trabecula carnea hypoplasia ( J:89215 )

• reduced trabeculation in the ventricular chamber