Phenotypes Associated with This Genotype

Genotype
MGI:3039495

• Allelic Composition: Tg(Apcs-Lep)1Yog/0
• Genetic Background: involves: C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

decreased brown adipose tissue amount ( J:69591 )

• the amount of interscapular brown adipose tissue is reduced compared to non-transgenic littermates

• the interscapular brown adipose tissue is more eosinophilic than that in to non-transgenic littermates

decreased white adipose tissue amount ( J:69591 )

• no subcutaneous white adipose tissue is seen in transgenic mice

behavior/neurological

abnormal food intake ( J:69591 )

• food intake is significantly reduced in transgenic mice reduced compared to non-transgenic littermates

endocrine/exocrine glands

small pancreatic islets ( J:69591 )

• the size of the pancreatic islets is reduced in transgenic mice compared to non-transgenic littermates

growth/size/body

decreased body weight ( J:69591 )

• transgenic mice are thinner than non-transgenic littermates

• by 4 weeks transgenic mice are significantly smaller than non-transgenic littermates

homeostasis/metabolism

abnormal glucose homeostasis ( J:69591 )

decreased circulating glucose level ( J:69591 )

• fed plasma glucose is lower in transgenic mice than in non-transgenic littermates

decreased circulating insulin level ( J:69591 )

• plasma insulin levels are lower in transgenic mice than in non-transgenic littermates

increased insulin sensitivity ( J:69591 )

• glucose and insulin tolerance tests reveal increased insulin sensitivity in transgenic mice compared to non-transgenic littermates

abnormal lipid level ( J:69591 )

decreased circulating free fatty acids level ( J:69591 )

• plasma free fatty acid levels are lower in transgenic mice than in non-transgenic littermates

decreased circulating triglyceride level ( J:69591 )

• plasma triglyceride levels are lower in transgenic mice than in non-transgenic littermates

liver/biliary system

small liver ( J:69591 )

• the liver is smaller in transgenic mice reduced compared to non-transgenic littermates

• the liver is also darker than normal in transgenic mice