Phenotypes for Il13 MGI:3038327 MGI Mouse

increased susceptibility to parasitic infection induced morbidity/mortality ( J:60609 )

• increased mortality following chronic infection with Schistosoma mansoni compared to wild-type mice

increased eosinophil cell number ( J:113543 )

• eosinophilia is delayed compared to wild-type, but correlates with worm expulsion after induction

abnormal immune system physiology ( J:89095 )

• homozygotes are otherwise healthy and fertile

decreased IgE level ( J:72587 , J:113543 )

• in Leishmania mexicana infected mice compared to wild-type mice (J:72587)

• mutants fail to produce IgE, due to deletion of Il4 (J:113543)

decreased IgG level ( J:89095 )

• IgG1 response to immunization with the protein antigen OVA is severely impaired

decreased IgG1 level ( J:72587 )

• in Leishmania mexicana infected mice compared to wild-type mice

abnormal T-helper 2 physiology ( J:89095 )

• homozygotes do not develop pulmonary granuloma formation in response to schistosome egg immunization

• eosinophil infiltration is absent in response to schistosome egg immunization

• impaired responses are greater than those seen in Il4^tm1Cgn and Il13^tm2Anjm homozygotes

abnormal splenocyte physiology ( J:72587 )

• Leishmania mexicana antigen stimulated cells from L. mexicana infected mice produce increased amounts of IL12 and IFNG

granulomatous inflammation ( J:113543 )

• primary granuloma formation and volumes in lungs after Scistosoma infection are severely reduced (<10%) compared to wild-type

• secondary granuloma formation is reduced vs wild-type after second exposure to parasite eggs

abnormal susceptibility to infection ( J:113543 )

• expulsion of worms from intestines (50% by day 25) is delayed compared to wild-type

decreased susceptibility to parasitic infection ( J:72587 )

• highly resistant to development of Leishmania mexicana induced skin lesions

• at 12 weeks after Leishmania mexicana infection the number of parasites is reduced compared to wild-type mice

increased susceptibility to parasitic infection ( J:89095 , J:113543 )

• the expulsion of parasitic worms from the gut is delayed (J:89095)

• this delay is longer than that seen in Il13^tm2Anjm homozygotes (J:89095)

• after N. brasiliensis (nematode) infection, expulsion of worms from intestines is delayed with ~50% of worms remaining in intestine after 25 days, whereas wild-type mice expel all worms within 5-10 days (J:113543)