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Phenotypes Associated with This Genotype
Genotype
MGI:3038120
Allelic
Composition
Gata1tm1Mym/Gata1+
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata1tm1Mym mutation (0 available); any Gata1 mutation (42 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• more than half of females die within 7 months of birth
• more than 50% of females die within 7 months of birth

hematopoietic system
• ectopic liver hematopoiesis
• variable severity
• mutants with severe splenomegaly that die spontaneously exhibit a diminished number of megakaryocytes in the enlarged spleens, however mutants with moderate splenomegaly, exhibit massive accumulation of megakaryocytes in the spleen
• massive accumulation of proerythroblasts in the spleen, resulting in almost no white pulp and only residual visible red pulp
• high numbers of proerythroblasts are seen in the peripheral blood of mice with severe anemia
• only residual red pulp due to massive accumulation of proerythroblasts in the spleen
• varying degrees of splenomegaly, with an accumulation of proerythroblasts and megakaryocytes
• almost no white pulp due to massive accumulation of proerythroblasts in the spleen

immune system
• only residual red pulp due to massive accumulation of proerythroblasts in the spleen
• varying degrees of splenomegaly, with an accumulation of proerythroblasts and megakaryocytes
• almost no white pulp due to massive accumulation of proerythroblasts in the spleen

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
myelodysplastic syndrome DOID:0050908 OMIM:614286
J:88685


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory