Analysis Tools
mortality/aging
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• incomplete penetrance
• whereas approximately one-third of males appeared healthy, others showed growth retardation, weakness, craniofacial defecfs, and died prior to weaning
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craniofacial
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• incomplete penetrance
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endocrine/exocrine glands
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• varying degrees of penetrance observed
• all three pituitary lobes are present at birth
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• varying degrees of penetrance observed
• altered development leading to the defects including disorganization and abnormalities of Rathke's pouch
• bifurcation of Rathke's pouch and the presence of extra Rathke's pouch clefts and linings
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• increased necrosis and empty tubules in the most severely affected mice
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growth/size/body
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• incomplete penetrance
• some males showed decreased growth and general weaknesss, these mice did not survive to weaning
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reproductive system
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• increased necrosis and empty tubules in the most severely affected mice
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nervous system
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• dysgenesis observed in the most severely affected mice
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• failure of the dorsal hippocampal commissure to cross the midline in the most severely affected mice
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• the floor plate was expanded relative to that of wild-type
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• varying degrees of penetrance observed
• all three pituitary lobes are present at birth
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• varying degrees of penetrance observed
• altered development leading to the defects including disorganization and abnormalities of Rathke's pouch
• bifurcation of Rathke's pouch and the presence of extra Rathke's pouch clefts and linings
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• abnormal continuity of the intercerebral fissure with the third ventricle in the most severely affected mice
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• the presumptive hypothalamus appeared thinner and shorter than that of wild-type embryos
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homeostasis/metabolism
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• in the pituitary
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• in the pituitary
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• in the pituitary
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