Analysis Tools
mortality/aging
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• a portion of mice died prior to weaning
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endocrine/exocrine glands
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• varying degrees of penetrance observed
• all three pituitary lobes are present at birth
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• varying degrees of penetrance observed
• altered development leading to the defects including disorganization and abnormalities of Rathke's pouch
• bifurcation of Rathke's pouch and the presence of extra Rathke's pouch clefts and linings
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• increased number of atretic follicles
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small ovary
(
J:88507
)
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• observed in some females and containing atretic follicles
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reproductive system
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N |
• normal sex determination
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• increased number of atretic follicles
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small ovary
(
J:88507
)
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• observed in some females and containing atretic follicles
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nervous system
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• dysgenesis observed in the most severely affected mice
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• failure of the dorsal hippocampal commissure to cross the midline in the most severely affected mice
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• the floor plate was expanded relative to that of wild-type
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• varying degrees of penetrance observed
• all three pituitary lobes are present at birth
|
|
|
• varying degrees of penetrance observed
• altered development leading to the defects including disorganization and abnormalities of Rathke's pouch
• bifurcation of Rathke's pouch and the presence of extra Rathke's pouch clefts and linings
|
|
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• abnormal continuity of the intercerebral fissure with the third ventricle in the most severely affected mice
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• the presumptive hypothalamus appeared thinner and shorter than that of wild-type embryos
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