Phenotypes Associated with This Genotype

Genotype
MGI:3035907

• Allelic Composition: Cd40^tm1Kik/Cd40^tm1Kik
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased neutrophil cell number ( J:25007 )

• in non-SPF facilities compared to wild-type controls

absent spleen germinal center ( J:25007 )

• failed to form

decreased immunoglobulin level ( J:25007 )

• reduced production of IgG1, IgG2a, IgG2b, IgG3, IgA, IgE in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• response to thymus-independent (TI) antigens was in tact

decreased IgA level ( J:25007 )

• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations in unimmunized mice

decreased IgE level ( J:25007 )

• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations in unimmunized mice

decreased IgG1 level ( J:25007 )

• reduced production of IgG1 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations of IgG1 in unimmunized mice

decreased IgG2a level ( J:25007 )

• reduced production of IgG2a in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations of IgG2a in unimmunized mice

decreased IgG2b level ( J:25007 )

• reduced production of IgG2b in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations of IgG2b in unimmunized mice

decreased IgG3 level ( J:25007 )

• reduced production of IgG3 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• IgG3 serum concentrations in unimmunized mice are not decreased

immune system

immune system phenotype ( J:25007 )

N • normal numbers and ratios of T and B cells

decreased neutrophil cell number ( J:25007 )

• in non-SPF facilities compared to wild-type controls

absent spleen germinal center ( J:25007 )

• failed to form

decreased susceptibility to type II hypersensitivity reaction ( J:61673 )

• in model of accelerated anti-glomerular basement membrane antibody-mediated glomerulonephritis

• deposition of IgG and complement in glomeruli not observed

• glomeruli almost normal

• fibrin deposition in glomeruli not observed

• failure to induce proteinuria

abnormal humoral immune response ( J:25007 )

decreased immunoglobulin level ( J:25007 )

• reduced production of IgG1, IgG2a, IgG2b, IgG3, IgA, IgE in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• response to thymus-independent (TI) antigens was in tact

decreased IgA level ( J:25007 )

• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations in unimmunized mice

decreased IgE level ( J:25007 )

• reduced production in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations in unimmunized mice

decreased IgG1 level ( J:25007 )

• reduced production of IgG1 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations of IgG1 in unimmunized mice

decreased IgG2a level ( J:25007 )

• reduced production of IgG2a in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations of IgG2a in unimmunized mice

decreased IgG2b level ( J:25007 )

• reduced production of IgG2b in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• decreased serum concentrations of IgG2b in unimmunized mice

decreased IgG3 level ( J:25007 )

• reduced production of IgG3 in response to thymus-dependent (TD) antigen, dintrophenol-conjugated ovalbumin

• IgG3 serum concentrations in unimmunized mice are not decreased