Phenotypes Associated with This Genotype

Genotype
MGI:3032769

• Allelic Composition: Thbs1^tm1Hyn/Thbs1^tm1Hyn; Trp53^tm1Tyj/Trp53^tm1Tyj
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:72391 )

• average life span of 149 days

neoplasm

increased pancreas tumor incidence ( J:72391 )

• 2.8% incidence of pancreas adenocarcinoma

increased lymphoma incidence ( J:72391 )

• 53% incidence

increased histiocytic sarcoma incidence ( J:72391 )

• 5.6% incidence

increased carcinoma incidence ( J:72391 )

• 8.3% incidence

increased adenocarcinoma incidence ( J:72391 )

• 5.6% incidence of adenocarcinoma

• 2.8% incidence of pancreas adenocarcinoma

increased small intestine adenocarcinoma incidence ( J:72391 )

• 2.8% incidence

increased sarcoma incidence ( J:72391 )

• 39% incidence of sarcomas, however no osteosarcomas are seen as in single Trp53 mutants

• 5.6% incidence of undifferentiated sarcoma

increased fibrosarcoma incidence ( J:72391 )

• 8.3% incidence

increased hemangiosarcoma incidence ( J:72391 )

• 17% incidence

digestive/alimentary system

increased small intestine adenocarcinoma incidence ( J:72391 )

• 2.8% incidence

endocrine/exocrine glands

increased pancreas tumor incidence ( J:72391 )

• 2.8% incidence of pancreas adenocarcinoma