Phenotypes Associated with This Genotype

Genotype
MGI:2687217

• Allelic Composition: Cdkn2a^tm4Rdp/Cdkn2a^tm4Rdp; Kras^tm4Tyj/Kras⁺; Tg(Pdx1-cre)89.1Dam/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * CBA * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased tumor-free survival time ( J:87196 , J:116130 )

• complete penetrance of death due to invasive and metastic cancer by 11 weeks of age (J:87196)

• average tumor-free survival is 8.6 weeks (J:116130)

neoplasm

increased pancreas tumor incidence ( J:87196 , J:108298 )

• solid pancreatic tumors, frequently adhering to adjacent organs and the retroperitoneum (J:87196)

• tumors are highly invasive, frequently involving the duodenum, stomach, liver and/or spleen and occasionally obstructing the common bile duct (J:87196)

• 26% of tumors exhibit anaplastic carcinoma histology (J:108298)

• 26% of tumors exhibit sarcomatoid differentiation (J:108298)

increased pancreatic ductal adenocarcinoma incidence ( J:87196 , J:108298 , J:116130 )

• tumors exhibit pathologic features of human pancreatic ductal adenocarcinomas (J:87196)

• 48% of tumors exhibit well differentiated ductal adenocarcinoma histology (J:108298)

• 6 of 6 mice develop pancreatic ductal adenocarcinoma (J:116130)

increased pancreatic intraepithelial neoplasia incidence ( J:87196 )

• earlier onset (3-4 weeks of age) of local premalignant ductal lesions (pancreatic intraepithelial neoplasia) than in mice just expressing the oncogenic form KRAS2 and not deficient for Cdkn2a expression

• pancreatic ductal lesions progress rapidly to invasive pancreatic adenocarcinoma

increased metastatic potential ( J:87196 , J:108298 )

• neoplasms frequently invade the lymphatic and vascular system, indicating metastatic invasion (J:87196)

• 11% of tumors exhibit metastasis (J:108298)

increased malignant tumor incidence ( J:87196 )

• neoplasms rapidly progressed to become invasive and metastatic tumors

endocrine/exocrine glands

increased pancreas tumor incidence ( J:87196 , J:108298 )

• solid pancreatic tumors, frequently adhering to adjacent organs and the retroperitoneum (J:87196)

• tumors are highly invasive, frequently involving the duodenum, stomach, liver and/or spleen and occasionally obstructing the common bile duct (J:87196)

• 26% of tumors exhibit anaplastic carcinoma histology (J:108298)

• 26% of tumors exhibit sarcomatoid differentiation (J:108298)

increased pancreatic ductal adenocarcinoma incidence ( J:87196 , J:108298 , J:116130 )

• tumors exhibit pathologic features of human pancreatic ductal adenocarcinomas (J:87196)

• 48% of tumors exhibit well differentiated ductal adenocarcinoma histology (J:108298)

• 6 of 6 mice develop pancreatic ductal adenocarcinoma (J:116130)

increased pancreatic intraepithelial neoplasia incidence ( J:87196 )

• earlier onset (3-4 weeks of age) of local premalignant ductal lesions (pancreatic intraepithelial neoplasia) than in mice just expressing the oncogenic form KRAS2 and not deficient for Cdkn2a expression

• pancreatic ductal lesions progress rapidly to invasive pancreatic adenocarcinoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pancreatic ductal adenocarcinoma		DOID:3498		J:87196 , J:108298