Phenotypes Associated with This Genotype

Genotype
MGI:2684121

• Allelic Composition: Itga4^tm1Tpa/Itga4^tm1Tpa; Tg(Mx1-cre)1Cgn/?
• Genetic Background: involves: 129S4/SvJaeSor * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

abnormal definitive hematopoiesis ( J:86861 )

• circulating progenitor cells in the peripheral blood increased 10X in 2 weeks

• levels were also increased in the spleen

• circulating progenitor cell levels remained high for 28 weeks although they moderated over time

• slow recovery of progenitor cell levels in bone marrow

abnormal B cell differentiation ( J:86861 )

• moderately reduced B220+ B cells

abnormal myeloblast morphology/development ( J:86861 )

decreased CD4-positive, alpha-beta T cell number ( J:86861 )

• moderately reduced CD4+ T cells

increased leukocyte cell number ( J:86861 )

• significantly increased WBC count in peripheral blood

• mostly due to circulating lymphocytes

abnormal reticulocyte morphology ( J:86861 )

• levels of reticulocytes and erythroid progenitors in general were depressed

• slow recovery from experimental anemia

immune system

abnormal B cell differentiation ( J:86861 )

• moderately reduced B220+ B cells

decreased CD4-positive, alpha-beta T cell number ( J:86861 )

• moderately reduced CD4+ T cells

increased leukocyte cell number ( J:86861 )

• significantly increased WBC count in peripheral blood

• mostly due to circulating lymphocytes