Analysis Tools
mortality/aging
|
• 50% of mice that were liveborn died before 3 weeks of age
|
|
• death between E7.5 and birth, incomplete penetrance
|
reproductive system
 |
• prepuberal testes contain less spermatogonia or spermatocytes per Sertoli cell
|
|
|
• seminiferous tubules exhibit increased numbers of apoptotic cells
|
small testis
(
J:83730
)
|
|
|
|
|
• testes show reduced weight beginning at 3 weeks of age, with average weight 67% of that of controls, with further reduction to 50% at 4 weeks of age
|
|
|
• spermatogenesis is disrupted, with a fraction of seminiferous tubules showing tubular vacuolization
(J:88035)
• disrupted
(J:83730)
|
|
|
• sperm count is reduced by 80% compared to wild-type mice
(J:88035)
(J:83730)
|
nervous system
|
• evident at E9.5 and in liveborn mice that died before 3 weeks of age
|
|
• evident in 33% of mice that survived past 6 weeks of age
|
|
• evident in 33% of mice that survived past 6 weeks of age
|
|
• collapsed, evident at E9.5
|
cardiovascular system
|
• evident at E9.5 and in liveborn mice that died before 3 weeks of age
|
endocrine/exocrine glands
|
|
• seminiferous tubules exhibit increased numbers of apoptotic cells
|
small testis
(
J:83730
)
|
|
|
|
|
• testes show reduced weight beginning at 3 weeks of age, with average weight 67% of that of controls, with further reduction to 50% at 4 weeks of age
|
cellular
|
|
• prepuberal testes contain less spermatogonia or spermatocytes per Sertoli cell
|
|
|
• sperm count is reduced by 80% compared to wild-type mice
(J:88035)
(J:83730)
|
