Phenotypes Associated with This Genotype

Genotype
MGI:2669328

• Allelic Composition: Tgfbr2^tm1Karl/Tgfbr2^tm1Karl; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:77844 )

• after induction with polyI:polyC, death 8 - 10 weeks after

behavior/neurological

abnormal stationary movement ( J:77844 )

• after induction with polyI:polyC, unsteady

paralysis ( J:77844 )

• after induction with polyI:polyC

digestive/alimentary system

stomach inflammation ( J:77844 )

• after induction with polyI:polyC

endocrine/exocrine glands

small thymus ( J:77844 )

• after induction with polyI:polyC

pancreas inflammation ( J:77844 )

• after induction with polyI:polyC

growth/size/body

weight loss ( J:77844 )

• after induction with polyI:polyC, dramatic

immune system

small thymus ( J:77844 )

• after induction with polyI:polyC

increased inflammatory response ( J:77844 )

• after induction with polyI:polyC

stomach inflammation ( J:77844 )

• after induction with polyI:polyC

pancreas inflammation ( J:77844 )

• after induction with polyI:polyC

eye inflammation ( J:77844 )

• after induction with polyI:polyC

liver inflammation ( J:77844 )

• after induction with polyI:polyC

liver/biliary system

liver inflammation ( J:77844 )

• after induction with polyI:polyC

vision/eye

eye inflammation ( J:77844 )

• after induction with polyI:polyC

hematopoietic system

small thymus ( J:77844 )

• after induction with polyI:polyC