Mouse Genome Informatics
hm
    Grk1tm1Citb/Grk1tm1Citb
involves: 129X1/SvJ * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
       

Altered morphology of Grk1tm1Citb/Grk1tm1Citb retina

vision/eye
• light-induced apoptosis of rods
• impaired rhodopsin deactivation
• rod outer segments of mice raised in 12 hour cyclic illumination are 50% shorter than those of wild-type or mutant mice raised in darkness at 6 weeks of age
• however, retinas of mutants born and raised in darkness are normal
• mutants transferred from cyclic illumination to total darkness exhibit shortening of the outer segments, but to a smaller extent than see in mutants born and raised in cyclic illumination
• when dark raised mutants are kept in continuous room light for 24 hours, retinas exhibit severe degeneration that is not observed in wild-type mice; degeneration is due to apoptosis
• flash responses of rods are greatly prolonged; the single-photon response consists of a long plateau, about 2-fold larger in amplitude than in control
• the prolonged response decays suddenly and rapidly at variable times

nervous system
• impaired rhodopsin deactivation
• rod outer segments of mice raised in 12 hour cyclic illumination are 50% shorter than those of wild-type or mutant mice raised in darkness at 6 weeks of age
• however, retinas of mutants born and raised in darkness are normal
• mutants transferred from cyclic illumination to total darkness exhibit shortening of the outer segments, but to a smaller extent than see in mutants born and raised in cyclic illumination
• when dark raised mutants are kept in continuous room light for 24 hours, retinas exhibit severe degeneration that is not observed in wild-type mice; degeneration is due to apoptosis

cellular
• light-induced apoptosis of rods

Mouse Models of Human Disease
OMIM IDRef(s)
Oguchi Disease 2 613411 J:54021