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Phenotypes Associated with This Genotype
Genotype
MGI:2668598
Allelic
Composition
Grk1tm1Citb/Grk1tm1Citb
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grk1tm1Citb mutation (0 available); any Grk1 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Altered morphology of Grk1tm1Citb/Grk1tm1Citb retina

vision/eye
• light-induced apoptosis of rods (J:54021)
• light-induced apoptosis of rods (J:54021)
• impaired rhodopsin deactivation (J:54021)
• impaired rhodopsin deactivation (J:54021)
• rod outer segments of mice raised in 12 hour cyclic illumination are 50% shorter than those of wild-type or mutant mice raised in darkness at 6 weeks of age (J:54021)
• however, retinas of mutants born and raised in darkness are normal (J:54021)
• mutants transferred from cyclic illumination to total darkness exhibit shortening of the outer segments, but to a smaller extent than see in mutants born and raised in cyclic illumination (J:54021)
• rod outer segments of mice raised in 12 hour cyclic illumination are 50% shorter than those of wild-type or mutant mice raised in darkness at 6 weeks of age (J:54021)
• however, retinas of mutants born and raised in darkness are normal (J:54021)
• mutants transferred from cyclic illumination to total darkness exhibit shortening of the outer segments, but to a smaller extent than see in mutants born and raised in cyclic illumination (J:54021)
• when dark raised mutants are kept in continuous room light for 24 hours, retinas exhibit severe degeneration that is not observed in wild-type mice; degeneration is due to apoptosis (J:54021)
• when dark raised mutants are kept in continuous room light for 24 hours, retinas exhibit severe degeneration that is not observed in wild-type mice; degeneration is due to apoptosis (J:54021)
• flash responses of rods are greatly prolonged; the single-photon response consists of a long plateau, about 2-fold larger in amplitude than in control (J:54021)
• the prolonged response decays suddenly and rapidly at variable times (J:54021)
• flash responses of rods are greatly prolonged; the single-photon response consists of a long plateau, about 2-fold larger in amplitude than in control (J:54021)
• the prolonged response decays suddenly and rapidly at variable times (J:54021)

nervous system
• impaired rhodopsin deactivation (J:54021)
• impaired rhodopsin deactivation (J:54021)
• rod outer segments of mice raised in 12 hour cyclic illumination are 50% shorter than those of wild-type or mutant mice raised in darkness at 6 weeks of age (J:54021)
• however, retinas of mutants born and raised in darkness are normal (J:54021)
• mutants transferred from cyclic illumination to total darkness exhibit shortening of the outer segments, but to a smaller extent than see in mutants born and raised in cyclic illumination (J:54021)
• rod outer segments of mice raised in 12 hour cyclic illumination are 50% shorter than those of wild-type or mutant mice raised in darkness at 6 weeks of age (J:54021)
• however, retinas of mutants born and raised in darkness are normal (J:54021)
• mutants transferred from cyclic illumination to total darkness exhibit shortening of the outer segments, but to a smaller extent than see in mutants born and raised in cyclic illumination (J:54021)
• when dark raised mutants are kept in continuous room light for 24 hours, retinas exhibit severe degeneration that is not observed in wild-type mice; degeneration is due to apoptosis (J:54021)
• when dark raised mutants are kept in continuous room light for 24 hours, retinas exhibit severe degeneration that is not observed in wild-type mice; degeneration is due to apoptosis (J:54021)

cellular
• light-induced apoptosis of rods (J:54021)
• light-induced apoptosis of rods (J:54021)

Mouse Models of Human Disease
OMIM ID Ref(s)
Oguchi Disease 2 613411 J:54021


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory