Phenotypes Associated with This Genotype

Genotype
MGI:2662500

• Allelic Composition: Cdkn2b^tm1Bbd/Cdkn2b^tm1Bbd; Cdkn2c^tm1Bbd/Cdkn2c^tm1Bbd
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased tumor incidence ( J:63299 )

increased pituitary adenoma incidence ( J:63299 )

increased testis tumor incidence ( J:63299 )

♂ • testicular (Leydig cell) tumors

increased lymphoma incidence ( J:63299 )

increased sarcoma incidence ( J:63299 )

• angiosarcomas appear in aged mice

endocrine/exocrine glands

increased pituitary adenoma incidence ( J:63299 )

abnormal mammary gland morphology ( J:63299 )

♀ • cysts in mammary glands

pancreas cyst ( J:63299 )

abnormal testis morphology ( J:63299 )

♂ • cysts in the testis

dilated rete testis ( J:63299 )

♂ • seen in 37.5% of males

seminiferous tubule degeneration ( J:63299 )

♂ • 37.5% of males show atrophy of the seminiferous tubes

enlarged testis ( J:63299 )

♂ • 37.5% of males show enlarged testes with severe dilatation of the tubules of the rete testis with atrophy of seminiferous tubes, similar to human testicular dysplasia

increased testis tumor incidence ( J:63299 )

♂ • testicular (Leydig cell) tumors

hematopoietic system

enlarged spleen ( J:63299 )

extramedullary hematopoiesis ( J:63299 )

abnormal Langerhans cell morphology ( J:63299 )

• Langerhans islet hyperplasia

abnormal lymphocyte morphology ( J:63299 )

• lymphocytes show increased proliferation upon mitogenic stimulation

immune system

enlarged spleen ( J:63299 )

abnormal Langerhans cell morphology ( J:63299 )

• Langerhans islet hyperplasia

abnormal lymphocyte morphology ( J:63299 )

• lymphocytes show increased proliferation upon mitogenic stimulation

lymph node hyperplasia ( J:63299 )

lymphoid hyperplasia ( J:63299 )

• 55% of mutants develop lymphoproliferative disorders to a similar extent as single Cdkn2b homozygotes

renal/urinary system

kidney cyst ( J:63299 )

reproductive system

abnormal testis morphology ( J:63299 )

♂ • cysts in the testis

dilated rete testis ( J:63299 )

♂ • seen in 37.5% of males

seminiferous tubule degeneration ( J:63299 )

♂ • 37.5% of males show atrophy of the seminiferous tubes

enlarged testis ( J:63299 )

♂ • 37.5% of males show enlarged testes with severe dilatation of the tubules of the rete testis with atrophy of seminiferous tubes, similar to human testicular dysplasia

increased testis tumor incidence ( J:63299 )

♂ • testicular (Leydig cell) tumors

cellular

abnormal cell physiology ( J:63299 )

• MEFs are susceptible to oncogenic ras transformation

increased fibroblast proliferation ( J:63299 )

• MEFs exhibit a higher proliferation rate and plating efficiency than wild-type MEFs, similar to single Cdkn2b homozygotes

integument

abnormal mammary gland morphology ( J:63299 )

♀ • cysts in mammary glands

nervous system

increased pituitary adenoma incidence ( J:63299 )

growth/size/body

pancreas cyst ( J:63299 )

kidney cyst ( J:63299 )

enlarged spleen ( J:63299 )