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Phenotypes Associated with This Genotype
Genotype
MGI:2657004
Allelic
Composition		 Cd19tm1(cre)Cgn/Cd19+
Ikbkbtm2Mka/Ikbkbtm2Mka
Genetic
Background		 involves: 129/Sv * 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19tm1(cre)Cgn mutation (12 available); any Cd19 mutation (57 available)
Ikbkbtm2Mka mutation (0 available); any Ikbkb mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
increased B cell apoptosis ( J:82995 )
• decrease in survival of B cells
decreased B cell number ( J:82995 )
• reduction in populations of some peripheral B cell subsets, particularly the lymph node compartment
• B cell generation is not impaired
decreased B-1 B cell number ( J:82995 )
• reduced number of peritoneal B-1 cells
abnormal B cell activation ( J:82995 )
• mutants fail to mount effective antibody responses to T cell-dependent and independent antigens
decreased B cell proliferation ( J:82995 )
• hypoproliferation in response to anti-IgM, LPS, and anti-Tnfrsf5 (anti9-CD40)
decreased IgG level ( J:82995 )
• decrease in basal IgG levels
decreased IgM level ( J:82995 )
• decrease in basal IgM levels

immune system
increased B cell apoptosis ( J:82995 )
• decrease in survival of B cells
decreased B cell number ( J:82995 )
• reduction in populations of some peripheral B cell subsets, particularly the lymph node compartment
• B cell generation is not impaired
decreased B-1 B cell number ( J:82995 )
• reduced number of peritoneal B-1 cells
abnormal B cell activation ( J:82995 )
• mutants fail to mount effective antibody responses to T cell-dependent and independent antigens
decreased B cell proliferation ( J:82995 )
• hypoproliferation in response to anti-IgM, LPS, and anti-Tnfrsf5 (anti9-CD40)
decreased IgG level ( J:82995 )
• decrease in basal IgG levels
decreased IgM level ( J:82995 )
• decrease in basal IgM levels

cellular
increased B cell apoptosis ( J:82995 )
• decrease in survival of B cells
decreased B cell proliferation ( J:82995 )
• hypoproliferation in response to anti-IgM, LPS, and anti-Tnfrsf5 (anti9-CD40)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory