Analysis Tools
immune system
| N |
• GM-CSF levels are comparable to levels in wild-type or Sell-null mutants; elevation observed in Sele/Selp double null mice is absent
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• neutrophil influx to the peritoneal cavity during thioglycolate-induced peritonitis is significantly reduced compared to wild-type animals in this model
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• rolling is severely compromised; no rolling is seen up to 5 hours after cremaster muscle exteriorization
• rolling flux and rolling fraction are more reduced than the decrease observed in Sele/Selp double null mice
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• white blood cell counts (total, eosinophil, neutrophil, monocyte counts) are significantly elevated compared to wild-type, but are ~half the value found in Sele/Selp double mutants
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• in liver parenchyma and sinusoids, neutrophil numbers are ~2-fold higher in mutants after Gal/ET treatment; numbers of neutrophils in liver tissue are significantly elevated 4 hours prior to Gal/ET treatment, compared to controls
(J:106550)
• more neutrophils accumulate in the hepatic vascular beds (sinusoids and venules) after Gal/ET treatment in mutants than in wild-type controls
(J:106550)
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• moderate disruption of splenic architecture is observed
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• lymphoid follicles of the white pulp are identified occasionally and have irregular shapes and sizes
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• irregular
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• both old and young mice show severe cervical lymphadenopathy, compared to wild-type or Sell-null mice; condition is more severe than in Sele/Selp/Sell-triple null mice
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• both old and young mice show marked cervical lymphadenopathy, compared to wild-type or Sell-null mice; condition is less severe than in Sele/Sell-double null mice
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• both old and younger mice show bronchial lymphoid aggregates
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hematopoietic system
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• neutrophil influx to the peritoneal cavity during thioglycolate-induced peritonitis is significantly reduced compared to wild-type animals in this model
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• rolling is severely compromised; no rolling is seen up to 5 hours after cremaster muscle exteriorization
• rolling flux and rolling fraction are more reduced than the decrease observed in Sele/Selp double null mice
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• mice show moderate extramedullary hematopoiesis in sinusoid of red pulp
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• white blood cell counts (total, eosinophil, neutrophil, monocyte counts) are significantly elevated compared to wild-type, but are ~half the value found in Sele/Selp double mutants
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• in liver parenchyma and sinusoids, neutrophil numbers are ~2-fold higher in mutants after Gal/ET treatment; numbers of neutrophils in liver tissue are significantly elevated 4 hours prior to Gal/ET treatment, compared to controls
(J:106550)
• more neutrophils accumulate in the hepatic vascular beds (sinusoids and venules) after Gal/ET treatment in mutants than in wild-type controls
(J:106550)
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• moderate disruption of splenic architecture is observed
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• lymphoid follicles of the white pulp are identified occasionally and have irregular shapes and sizes
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• irregular
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respiratory system
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• both old and younger mice show bronchial lymphoid aggregates
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• lung tissue displays decreasing cellularity within alveolocapillary walls, but this is less severe than in Sele/Selp double-nulls
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• only a small increase in leukocytes in alveolocapillary walls are observed and occasional small bronchial lymphoid aggregates are found
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cardiovascular system
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• only a small increase in leukocytes in alveolocapillary walls are observed and occasional small bronchial lymphoid aggregates are found
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liver/biliary system
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• at 7 hours after galactosamine/bacterial endotoxin (Gal/ET) treatment, area on necrosis is attenuated 68% compared to treated controls
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• mutants show decreased liver injury relative to treated controls at 7 hours after treatment with Gal/ET
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homeostasis/metabolism
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• at 7 hours after galactosamine/bacterial endotoxin (Gal/ET) treatment, plasma ALT levels are reduced by 65% compared to treated controls
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integument
| N |
• mice do not show skin ulcerations as seen in double Sele/Selp mutants
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cellular
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• at 7 hours after galactosamine/bacterial endotoxin (Gal/ET) treatment, area on necrosis is attenuated 68% compared to treated controls
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• neutrophil influx to the peritoneal cavity during thioglycolate-induced peritonitis is significantly reduced compared to wild-type animals in this model
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• rolling is severely compromised; no rolling is seen up to 5 hours after cremaster muscle exteriorization
• rolling flux and rolling fraction are more reduced than the decrease observed in Sele/Selp double null mice
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