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Phenotypes Associated with This Genotype
Genotype
MGI:2654709
Allelic
Composition
Lepob/Lepob
Genetic
Background
involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepob mutation (5 available); any Lep mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system

growth/size/body
• heart weight elevated relative to controls
• increase in lean mass at 8 and 16 weeks of age
• increase in weight gain in a short period of time (J:219118)
• pair fed mice restrict food intake to that of controls
• pair fed mice gain less weight as protein than when feeding is unrestricted
• pair fed mice gain considerably more weight as fat than controls eating the same quantity of food
• pair fed mice gain less weight than when feeding is unrestricted

endocrine/exocrine glands
• increased number of mucus filled goblet cells in the colon
• increase in the size of islets of Langerhans and appearance of enormous islets in the pancreas of 30 week old mice
• lower threshold for glucose induced insulin secretion by beta cells (J:14402)
• acetyl choline has a greater affect to lower the glucose induced threshold for insulin secretion (J:22634)

mortality/aging
• 50 % higher postnatal death rate of males

homeostasis/metabolism
• lower threshold for glucose induced insulin secretion by beta cells (J:14402)
• acetyl choline has a greater affect to lower the glucose induced threshold for insulin secretion (J:22634)
• fasting mice show increased glucose levels at 6 weeks of age
• observed prior to any significant increase in body weight (J:86303)
• in the insulin tolerance test, mice reduce their glucose levels within 30 min to about 80% compared to 50% in wild-type mice at 6 weeks of age
• mice do not respond to insulin in the insulin tolerance test at 15 weeks of age, indicating insulin resistance
• corticosterone response to stress greater than in controls
• diurnal variation greater than in controls
• levels in the pituitary are much higher than in pituitaries of controls

skeleton
• denser vertebrae and long bones at 6 months
• increased bone mass even on a low fat diet to delay obesity
• increased numbers of thick trabeculae at 3 and 6 months
• 2 fold increase in trabecular bone volume
• rate of new bone formation increased at both 3 and 6 months
• increased numbers of osteoclasts

hematopoietic system
• increased numbers of osteoclasts

adipose tissue
• increase in area size of epigonadal fat cells (J:219118)
• increase in epigonadal fat tissue weight
• increase in fat mass at 8 and 16 weeks of age

digestive/alimentary system
• thick mucus gel covers the epithelium of the colon
• increased number of mucus filled goblet cells in the colon

cardiovascular system
• neovascularization is significantly suppressed under standard oxygen conditions relative to controls
• heart weight elevated relative to controls
• attenuated heart response to increased calcium
• oxygen consumption of the heart does not increase with an increased workload
• oxygen consumption is elevated when perfused with glucose and palmitate

muscle
• basal calcium ion concentration increases sharply toward the end of a series of 50 tetanic contractions (single cell measures)
• number of tetani required to reduce force by 40% is significantly less than for controls

vision/eye
• neovascularization is significantly suppressed under standard oxygen conditions relative to controls

nervous system
• 16% lower motor nerve conduction velocity than controls
• hind limb sensory nerve conduction velocity reduced 22%

behavior/neurological
• faster in food finding trials relative to controls
• mice eat twice as much as wild-type mice
• 88% increased latency of hind-limb withdrawal from a heat stimulus

immune system
• increased numbers of osteoclasts

cellular
• increased number of mucus filled goblet cells in the colon
• increased numbers of osteoclasts
• mitochondrial respiration is inhibited in glucose perfused hearts
• increased ADP dependent mitochondrial respiration in glucose and palmitate perfused hearts
• mitochondrial respiration is uncoupled in glucose and palmitate perfused hearts

integument
• significant reduction in intraepidermal nerve fiber density

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
abdominal obesity-metabolic syndrome 1 DOID:14221 OMIM:605552
J:219118


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory