Phenotypes Associated with This Genotype

Genotype
MGI:2653526

• Allelic Composition: Ikzf1^tm1(Pax5)Mbu/Ikzf1^tm1(Pax5)Mbu; Tg(Mx1-cre)1Cgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

thymus hypoplasia ( J:80815 )

• at day 6, cellularity is low and decreases further until day 23

increased early pro-B cell number ( J:80815 )

• there is 17-fold expansion of early pro-B cells, until day 23

abnormal T cell differentiation ( J:80815 )

• numbers of double positive thymocytes is reduced, while double positive numbers are increased relative to controls

arrested T cell differentiation ( J:80815 )

• partial block at DN3 stage is observed

increased B cell number ( J:80815 )

• upon induction of transgene, bone marrow contains ~9 times more B lmphocytes compared to control

immune system

thymus hypoplasia ( J:80815 )

• at day 6, cellularity is low and decreases further until day 23

increased early pro-B cell number ( J:80815 )

• there is 17-fold expansion of early pro-B cells, until day 23

abnormal T cell differentiation ( J:80815 )

• numbers of double positive thymocytes is reduced, while double positive numbers are increased relative to controls

arrested T cell differentiation ( J:80815 )

• partial block at DN3 stage is observed

increased B cell number ( J:80815 )

• upon induction of transgene, bone marrow contains ~9 times more B lmphocytes compared to control

endocrine/exocrine glands

thymus hypoplasia ( J:80815 )

• at day 6, cellularity is low and decreases further until day 23