Phenotypes Associated with This Genotype

Genotype
MGI:2652214

• Allelic Composition: Tg(Thy1-SNCA*A30P)18Pjk/Tg(Thy1-SNCA*A30P)18Pjk
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

hunched posture ( J:80181 )

abnormal tail movements ( J:80181 )

• abnormal tail posture

• jerky tail movements

abnormal locomotor behavior ( J:80181 )

abnormal gait ( J:80181 )

• unsteady gait

hindlimb paralysis ( J:80181 )

muscle

progressive muscle weakness ( J:80181 )

• hindlimb weakness appears first with forelimb weakness appearing later; leads to hindlimb paralysis

nervous system

gliosis ( J:80181 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 1		DOID:0060367	OMIM:168601	J:80181