About   Help   FAQ
Transgene Detail
Symbol: Tg(Thy1-SNCA*A30P)18Pjk
Name: transgene insertion 18, Philipp J Kahle
MGI ID: MGI:2445720
Synonyms: [A30P]alphaSYN, Tg(Thy1-SNCA-A30P)18Pjk, Tg(Thy1-SNCA-A30P)1Pjk, (Thy1)-h[A30P]alphaS, ThyA30P18, Thy-A30P18
Transgene: Tg(Thy1-SNCA*A30P)18Pjk  Location: unknown  
Alliance: Tg(Thy1-SNCA*A30P)18Pjk page
Strain of Origin:  C57BL/6
Transgene Type:    Transgenic (Inserted expressed sequence)
Mutation:    Insertion
Tg(Thy1-SNCA*A30P)18Pjk expresses 1 gene
Mutation detailsThe transgene is composed of a mouse Thy1 promoter, a human alpha synuclein (SNCA) cDNA encoding an alanine to proline substitution at amino acid 30 (A30P), and exon 4 of mouse Thy1, which contains polyadenylation signals. The A30P mutation is found in human patients with severe early onset Parkinson disease. Transgene expression is detected in the spinal cord and most areas of the brain except the substantia nigra. (J:64205)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Transgenic lines 18 and 31 expressed higher levels of the transgene than lines 8, 9, and 14.
Original:  J:64205 Kahle PJ, et al., Subcellular localization of wild-type and Parkinson's disease-associated mutant alpha -synuclein in human and transgenic mouse brain. J Neurosci. 2000 Sep 1;20(17):6365-73
All:  31 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Copyright, and Privacy Statement
Send questions and comments to User Support.
last database update
MGI 6.22
The Jackson Laboratory