Phenotypes Associated with This Genotype

Genotype
MGI:2651548

• Allelic Composition: Pax2^tm1Mbu/Pax2⁺; Pax8^tm1(cre)Mbu/Pax8⁺
• Genetic Background: involves: 129P2/OlaHsd * C3H/He * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

decreased renal glomerulus number ( J:80208 )

• at E18.5, glomeruli are reduced in number and abnormally arranged

abnormal metanephric mesenchyme morphology ( J:80208 )

• at E18.5, the uninduced mesenchyme at the cortex and the mesenchymal stroma are increased, indicating inefficient induction of nephric tubules

small metanephros ( J:80208 )

• at E18.5, the metanephros is bilaterally reduced to only ~25% of the size in control littermates

• however, all other components of the urogenital system develop normally

renal hypoplasia ( J:80208 )

decreased nephron number ( J:80208 )

• at E18.5, nephric tubules are reduced in number and abnormally arranged

• however, remaining nephrons are functional as mice survive to >18 months of age

reproductive system

vagina atresia ( J:80208 )

♀

blind vagina ( J:80208 )

♀ • Background Sensitivity: 100% penetrance on C57BL/6 x 129/Sv background; 43% penetrance on C3H background

♀ • minor malformations are still observed in open vaginas

reduced male fertility ( J:80208 )

♂ • a significant proportion of males fail to give produce any progeny; likely due to ductal obstruction of the genital tracts rather than a defect in sperm formation