Analysis Tools
mortality/aging
cardiovascular system
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• abnormal origin of the right subclavian artery
|
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• observed between E17.7-E18.5
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hemorrhage
(
J:81153
)
|
• midline hemorrhage
|
craniofacial
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• phenotype varied in severity; the frontal bones were absent or failed to fuse
|
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• phenotype varied in severity; the nasal bones were absent or failed to fuse
|
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• developmental defects appear at E11.5 with a gap in the frontal nasal processes and progresses to hemorrhaging and blebbing by E13.5
|
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• phenotype varied in severity; the nasal capsule was absent or failed to fuse
|
short snout
(
J:81153
)
|
• snouts shortened by 8%
|
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• phenotype varied in severity due to defects in the nasal capsule and/or frontal and nasal bones
|
immune system
small thymus
(
J:81153
)
|
• observed with very low penetrance (3 out of 32 homozygous mutant embryos)
|
skeleton
|
• phenotype varied in severity; the frontal bones were absent or failed to fuse
|
|
• phenotype varied in severity; the nasal bones were absent or failed to fuse
|
|
• phenotype varied in severity; the nasal capsule was absent or failed to fuse
|
hematopoietic system
small thymus
(
J:81153
)
|
• observed with very low penetrance (3 out of 32 homozygous mutant embryos)
|
respiratory system
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• phenotype varied in severity; the nasal bones were absent or failed to fuse
|
|
• phenotype varied in severity; the nasal capsule was absent or failed to fuse
|
endocrine/exocrine glands
small thymus
(
J:81153
)
|
• observed with very low penetrance (3 out of 32 homozygous mutant embryos)
|
growth/size/body
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• phenotype varied in severity; the frontal bones were absent or failed to fuse
|
|
• phenotype varied in severity; the nasal bones were absent or failed to fuse
|
|
• phenotype varied in severity; the nasal capsule was absent or failed to fuse
|
short snout
(
J:81153
)
|
• snouts shortened by 8%
|
|
• phenotype varied in severity due to defects in the nasal capsule and/or frontal and nasal bones
|
