Analysis Tools
immune system
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• normal bone marrow monocyte/macrophage transition to giant multinucleate cells (osteoclasts) induced by Cd4+ T cells and reduced levels of IFN-gamma
• IFN-gamma treatment of cultured bone marrow macrophage suppresses osteoclast formation
• suppression of signaling via NF-kappaB ligand decreases osteoclast formation
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• slightly decreased number of double positive thymocytes
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• slight increase in the thymus and spleen although the ratio of CD4+ to Cd8+ cells in the spleen is normal
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• no germinal center B cells in the spleens of immunized homozygotes but the architecture of the spleen is normal
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• primary response to T cell dependent antigens is severely reduced
• secondary response to T cell dependent antigens is lost
• T cell independent antibody responses are unaffected
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• level is profoundly reduced in older animals, but is normal at 6 weeks of age
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• level is profoundly reduced in older animals, but is normal at 6 weeks of age
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• level is profoundly reduced in older animals, but is normal at 6 weeks of age
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• level is profoundly reduced in older animals, but is normal at 6 weeks of age
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• level is profoundly reduced in older animals, but is normal at 6 weeks of age
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• CD4+ T cells unable to drive isotype switching from IgM to IgG1 although IgM levels remain normal
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skeleton
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• normal bone marrow monocyte/macrophage transition to giant multinucleate cells (osteoclasts) induced by Cd4+ T cells and reduced levels of IFN-gamma
• IFN-gamma treatment of cultured bone marrow macrophage suppresses osteoclast formation
• suppression of signaling via NF-kappaB ligand decreases osteoclast formation
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hematopoietic system
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• normal bone marrow monocyte/macrophage transition to giant multinucleate cells (osteoclasts) induced by Cd4+ T cells and reduced levels of IFN-gamma
• IFN-gamma treatment of cultured bone marrow macrophage suppresses osteoclast formation
• suppression of signaling via NF-kappaB ligand decreases osteoclast formation
|
|
|
• slightly decreased number of double positive thymocytes
|
|
|
• slight increase in the thymus and spleen although the ratio of CD4+ to Cd8+ cells in the spleen is normal
|
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• no germinal center B cells in the spleens of immunized homozygotes but the architecture of the spleen is normal
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• level is profoundly reduced in older animals, but is normal at 6 weeks of age
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• level is profoundly reduced in older animals, but is normal at 6 weeks of age
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• level is profoundly reduced in older animals, but is normal at 6 weeks of age
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• level is profoundly reduced in older animals, but is normal at 6 weeks of age
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• level is profoundly reduced in older animals, but is normal at 6 weeks of age
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• CD4+ T cells unable to drive isotype switching from IgM to IgG1 although IgM levels remain normal
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cellular
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• normal bone marrow monocyte/macrophage transition to giant multinucleate cells (osteoclasts) induced by Cd4+ T cells and reduced levels of IFN-gamma
• IFN-gamma treatment of cultured bone marrow macrophage suppresses osteoclast formation
• suppression of signaling via NF-kappaB ligand decreases osteoclast formation
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