About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:2177637
Allelic
Composition
Tfamtm1Lrsn/Tfamtm1Lrsn
Tg(Myhca-cre)1Lrsn/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfamtm1Lrsn mutation (0 available); any Tfam mutation (4 available)
Tg(Myhca-cre)1Lrsn mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 75% of animals die as neonates
• animals surviving past neonatal stage survive for several months; variable penetrance speculated to be the result of a modifying gene

cardiovascular system

cellular
• respiratory chain dysfunction in heart; variable penetrance speculated to be the result of a modifying gene

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Kearns-Sayre syndrome DOID:12934 OMIM:530000
J:61372


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/12/2019
MGI 6.13
The Jackson Laboratory