Analysis Tools
endocrine/exocrine glands
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• progressive weight reduction after 5 months of age, resulting in weights 10% those of normal at 14 months of age
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• tubules are devoid of germ cells by 6 months of age
• by 8 months of age most sertoli cells had sloughed off and there was reduction in the number of leydig cells
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small testis
(
J:46386
)
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nervous system
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• mitochondria lengths in Purkinje cells are 1.4-1.5 um, compared to lengths of 0.8-1.0 um in wild-type animals
• often, points where mitochondria become constricted are observed in mutants but not in wild-type mitochondria, suggestive of impaired fission
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• large numbers of naked dendritic spines are present
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• mismatched connections between pre- and postsynaptic active zones of Purkinje cell/parallel fiber synapses are frequently seen
• other synaptic defects such as shortened active zones and thickened postsynaptic densities
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behavior/neurological
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• mice fail to improve performance in rotating rod trials in contrast to wild-type animals
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reproductive system
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• degenerating spermatocytes are first observed at 19 days of age
• 10-fold decrease in the number of spermatids by 24 days of age
• all stages of developing germ cells were observed at 2.5 months of age, though most were lost by 5 months of age
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• progressive weight reduction after 5 months of age, resulting in weights 10% those of normal at 14 months of age
|
|
|
• tubules are devoid of germ cells by 6 months of age
• by 8 months of age most sertoli cells had sloughed off and there was reduction in the number of leydig cells
|
small testis
(
J:46386
)
|
|
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cellular
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• degenerating spermatocytes are first observed at 19 days of age
• 10-fold decrease in the number of spermatids by 24 days of age
• all stages of developing germ cells were observed at 2.5 months of age, though most were lost by 5 months of age
|
|
• mitochondria lengths in Purkinje cells are 1.4-1.5 um, compared to lengths of 0.8-1.0 um in wild-type animals
• often, points where mitochondria become constricted are observed in mutants but not in wild-type mitochondria, suggestive of impaired fission
|
homeostasis/metabolism
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• increased levels observed between 2.5 and 15 months of age
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