Phenotypes Associated with This Genotype

Genotype
MGI:2175750

• Allelic Composition: Cd19^tm1(cre)Cgn/Cd19^tm1(cre)Cgn
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal B cell differentiation ( J:27463 )

decreased B-1 B cell number ( J:83213 , J:27463 )

• reduced numbers of B1 cells (Cd23-, IgM hi, IgD lo) (J:27463)

absent spleen germinal center ( J:83213 , J:27463 )

• failure of germinal center formation (J:27463)

abnormal B cell physiology ( J:27463 )

• impaired B cell response to T cell dependent antigens; mutants exhibit a decreased hapten-specific antibody response by an NP-chicken-gamma-globulin conjugate

abnormal immunoglobulin level ( J:27463 )

• failure of affinity maturation of serum antibodies

decreased IgE level ( J:27463 )

decreased IgG1 level ( J:27463 )

• absence of high-affinity NP-specific IgG1 antibody following immunization with NP-chicken-gamma-globulin conjugate

decreased IgM level ( J:27463 )

• reduction in serum IgM

hematopoietic system

abnormal B cell differentiation ( J:27463 )

decreased B-1 B cell number ( J:83213 , J:27463 )

• reduced numbers of B1 cells (Cd23-, IgM hi, IgD lo) (J:27463)

absent spleen germinal center ( J:83213 , J:27463 )

• failure of germinal center formation (J:27463)

abnormal B cell physiology ( J:27463 )

• impaired B cell response to T cell dependent antigens; mutants exhibit a decreased hapten-specific antibody response by an NP-chicken-gamma-globulin conjugate

abnormal immunoglobulin level ( J:27463 )

• failure of affinity maturation of serum antibodies

decreased IgE level ( J:27463 )

decreased IgG1 level ( J:27463 )

• absence of high-affinity NP-specific IgG1 antibody following immunization with NP-chicken-gamma-globulin conjugate

decreased IgM level ( J:27463 )

• reduction in serum IgM