Phenotypes Associated with This Genotype

Genotype
MGI:2175171

• Allelic Composition: Nrg1^tm1Zhou/Nrg1^tm1Zhou
• Genetic Background: involves: 129S1/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:50592 )

• die at E10.5

cardiovascular system

cardiovascular system phenotype ( J:50592 )

N • endocardial cusion development appeared normal

trabecula carnea hypoplasia ( J:50592 )

decreased heart rate ( J:50592 )

• slow hearbeat

irregular heartbeat ( J:50592 )

muscle

trabecula carnea hypoplasia ( J:50592 )

nervous system

abnormal cranial ganglia morphology ( J:50592 )

• defects in cranial ganglion development were observed

small petrosal ganglion ( J:50592 )

• hypoplastic and disorganized projections

abnormal trigeminal ganglion morphology ( J:50592 )

• the dorsal part of the ganglion, the mandibular branch and the brain stem projections were absent

small nodose ganglion ( J:50592 )

• hypoplastic and disorganized projections

abnormal trigeminal nerve morphology ( J:50592 )

• smaller with poor organization; apoptosis evident

abnormal mandibular nerve branching ( J:50592 )

• absent