Nrg1^tm1Zhou
Targeted Allele Detail

Summary

• Symbol: Nrg1^tm1Zhou
• Name: neuregulin 1; targeted mutation 1, Mingdong Zhou
• MGI ID: MGI:1928830
• Synonyms: CT^-, deltaCT
• Gene: Nrg1 Location: Chr8:32299493-33381858 bp, - strand Genetic Position: Chr8, 18.75 cM
• Alliance: Nrg1^tm1Zhou page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50592
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Specific disruption of the intracellular domain of the Nrg1 gene. A stop codon and a poly(A) sequence was introduced immediately 3' to the coding region for the first three amino acids of the intracellular domain, followed by a neomycin cassette. (J:50592)
• Inheritance: Recessive

Expression

In Mice Carrying this Mutation:	11 assay results
In Structures Affected by this Mutation:	8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nrg1 Mutation: 53 strains or lines available

References

• Original: J:50592 Liu X, et al., Domain-specific gene disruption reveals critical regulation of neuregulin signaling by its cytoplasmic tail. Proc Natl Acad Sci U S A. 1998 Oct 27;95(22):13024-9
• All: 1 reference(s)