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Phenotypes Associated with This Genotype
Genotype
MGI:2174910
Allelic
Composition
Rag2tm1Fwa/Rag2tm1Fwa
Genetic
Background
involves: 129S/SvEv * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (37 available); any Rag2 mutation (74 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• smaller in size than wild-type or heterozygous littermates when maintained in nonbarrier facilities

immune system
• decrease in cellularity of the thymus
• inability to initiate V(D)J recombination
• B cell development is arrested at the point at which Ig gene rearrangement is initiated
• inability to initiate V(D)J recombination
• absent double positive cells in thymus
• majority of thymocytes are arrested at an early precursor stage of differentiation
• spleens contain increased numbers of granulocytes
• absent mature B lymphocytes; only very immature lymphoid cells are seen in primary lymphoid organs
• spleens contain increased numbers of macrophages
• absence of mature T cells
• absence of single positive cells in the thymus, although spleen contains a small population of CD4+ T cells
• absence of single positive cells in the thymus, although spleen contains a small population of CD8+ T cells
• spleens contain increased numbers of macrophages and granulocytes
• spleens contain 5-10 times fewer cells than control spleens
• absent IgM
• mutants have a higher level of splenic natural killer activity than controls
• mutants develop infections when maintained in nonbarrier facilities for several months

hematopoietic system
• decrease in cellularity of the thymus
• inability to initiate V(D)J recombination
• B cell development is arrested at the point at which Ig gene rearrangement is initiated
• inability to initiate V(D)J recombination
• absent double positive cells in thymus
• majority of thymocytes are arrested at an early precursor stage of differentiation
• spleens contain increased numbers of granulocytes
• absent mature B lymphocytes; only very immature lymphoid cells are seen in primary lymphoid organs
• spleens contain increased numbers of macrophages
• absence of mature T cells
• absence of single positive cells in the thymus, although spleen contains a small population of CD4+ T cells
• absence of single positive cells in the thymus, although spleen contains a small population of CD8+ T cells
• spleens contain increased numbers of macrophages and granulocytes
• spleens contain 5-10 times fewer cells than control spleens
• absent IgM
• mutants have a higher level of splenic natural killer activity than controls

endocrine/exocrine glands
• decrease in cellularity of the thymus


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory