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Phenotypes Associated with This Genotype
Genotype
MGI:2174910
Allelic
Composition
Rag2tm1Fwa/Rag2tm1Fwa
Genetic
Background
involves: 129S/SvEv * MF1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2tm1Fwa mutation (37 available); any Rag2 mutation (64 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• smaller in size than wild-type or heterozygous littermates when maintained in nonbarrier facilities (J:1935)
• smaller in size than wild-type or heterozygous littermates when maintained in nonbarrier facilities (J:1935)

immune system
• decrease in cellularity of the thymus (J:1935)
• decrease in cellularity of the thymus (J:1935)
• inability to initiate V(D)J recombination (J:1935)
• inability to initiate V(D)J recombination (J:1935)
• B cell development is arrested at the point at which Ig gene rearrangement is initiated (J:1935)
• B cell development is arrested at the point at which Ig gene rearrangement is initiated (J:1935)
• inability to initiate V(D)J recombination (J:1935)
• inability to initiate V(D)J recombination (J:1935)
• absent double positive cells in thymus (J:1935)
• absent double positive cells in thymus (J:1935)
• majority of thymocytes are arrested at an early precursor stage of differentiation (J:1935)
• majority of thymocytes are arrested at an early precursor stage of differentiation (J:1935)
• spleens contain increased numbers of granulocytes (J:1935)
• spleens contain increased numbers of granulocytes (J:1935)
• absent mature B lymphocytes; only very immature lymphoid cells are seen in primary lymphoid organs (J:1935)
• absent mature B lymphocytes; only very immature lymphoid cells are seen in primary lymphoid organs (J:1935)
• spleens contain increased numbers of macrophages (J:1935)
• spleens contain increased numbers of macrophages (J:1935)
• absence of mature T cells (J:1935)
• absence of mature T cells (J:1935)
• absence of single positive cells in the thymus, although spleen contains a small population of CD4+ T cells (J:1935)
• absence of single positive cells in the thymus, although spleen contains a small population of CD4+ T cells (J:1935)
• absence of single positive cells in the thymus, although spleen contains a small population of CD8+ T cells (J:1935)
• absence of single positive cells in the thymus, although spleen contains a small population of CD8+ T cells (J:1935)
• spleens contain increased numbers of macrophages and granulocytes (J:1935)
• spleens contain increased numbers of macrophages and granulocytes (J:1935)
• spleens contain 5-10 times fewer cells than control spleens (J:1935)
• spleens contain 5-10 times fewer cells than control spleens (J:1935)
• absent IgM (J:1935)
• absent IgM (J:1935)
• mutants have a higher level of splenic natural killer activity than controls (J:1935)
• mutants have a higher level of splenic natural killer activity than controls (J:1935)
• mutants develop infections when maintained in nonbarrier facilities for several months (J:1935)
• mutants develop infections when maintained in nonbarrier facilities for several months (J:1935)

hematopoietic system
• decrease in cellularity of the thymus (J:1935)
• decrease in cellularity of the thymus (J:1935)
• inability to initiate V(D)J recombination (J:1935)
• inability to initiate V(D)J recombination (J:1935)
• B cell development is arrested at the point at which Ig gene rearrangement is initiated (J:1935)
• B cell development is arrested at the point at which Ig gene rearrangement is initiated (J:1935)
• inability to initiate V(D)J recombination (J:1935)
• inability to initiate V(D)J recombination (J:1935)
• absent double positive cells in thymus (J:1935)
• absent double positive cells in thymus (J:1935)
• majority of thymocytes are arrested at an early precursor stage of differentiation (J:1935)
• majority of thymocytes are arrested at an early precursor stage of differentiation (J:1935)
• spleens contain increased numbers of granulocytes (J:1935)
• spleens contain increased numbers of granulocytes (J:1935)
• absent mature B lymphocytes; only very immature lymphoid cells are seen in primary lymphoid organs (J:1935)
• absent mature B lymphocytes; only very immature lymphoid cells are seen in primary lymphoid organs (J:1935)
• spleens contain increased numbers of macrophages (J:1935)
• spleens contain increased numbers of macrophages (J:1935)
• absence of mature T cells (J:1935)
• absence of mature T cells (J:1935)
• absence of single positive cells in the thymus, although spleen contains a small population of CD4+ T cells (J:1935)
• absence of single positive cells in the thymus, although spleen contains a small population of CD4+ T cells (J:1935)
• absence of single positive cells in the thymus, although spleen contains a small population of CD8+ T cells (J:1935)
• absence of single positive cells in the thymus, although spleen contains a small population of CD8+ T cells (J:1935)
• spleens contain increased numbers of macrophages and granulocytes (J:1935)
• spleens contain increased numbers of macrophages and granulocytes (J:1935)
• spleens contain 5-10 times fewer cells than control spleens (J:1935)
• spleens contain 5-10 times fewer cells than control spleens (J:1935)
• absent IgM (J:1935)
• absent IgM (J:1935)
• mutants have a higher level of splenic natural killer activity than controls (J:1935)
• mutants have a higher level of splenic natural killer activity than controls (J:1935)

endocrine/exocrine glands
• decrease in cellularity of the thymus (J:1935)
• decrease in cellularity of the thymus (J:1935)


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory