Phenotypes Associated with This Genotype

Genotype
MGI:2174826

• Allelic Composition: Tg(BMP4)6Blh/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:65030 )

prenatal lethality, incomplete penetrance ( J:65030 )

• 2/3 die before birth

pigmentation

irregular coat pigmentation ( J:65030 )

• hairs show irregular pigmentation and keratinization

growth/size/body

postnatal growth retardation ( J:65030 )

• variable severity of growth retardation

integument

abnormal coat appearance ( J:65030 )

• hairs are crooked

irregular coat pigmentation ( J:65030 )

• hairs show irregular pigmentation and keratinization

alopecia ( J:65030 )

• loss of hair with age

abnormal hair follicle morphology ( J:65030 )

• cell proliferation is completely absent in the bulb region and lower part of the outer root sheath of hair follicles

small hair follicles ( J:65030 )

abnormal vibrissa morphology ( J:65030 )

• vibrissae are either completely absent or produce only short stubby shafts

• cell proliferation is absent in the matrix cells and the outer root sheath of the mid-region of the whiskers

• whiskers are irregular in shape with degenerated layers of sheaths cells and tiny shafts

abnormal hair cycle ( J:65030 )

• hair follicles fail to initiate a second growth cycle, which leaves shed or lost hair unreplenished and leads to balding with age

thin dermal layer ( J:65030 )

abnormal skin physiology ( J:65030 )

• epidermis response to wax stripping is delayed, with epidermis thickening after 5 days instead of the expected 2 days after wax stripping the hair