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Phenotypes Associated with This Genotype
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Tyj mutation (8 available); any Trp53 mutation (141 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• 28% of mutants die by 17 months of age due to tumors (J:17728)
• heterozygous mutants die between 150 to 750 days after birth (J:95318)

• tumors show loss of heterozygosity for Trp53
• age of onset 9 months
• 5.9% incidence
• 25% of mutants exhibit lymphomas (J:17728)
• 32% incidence (J:72391)
• 32% of heterozygous mutants developed lymphomas (J:95318)
• 35% incidence of carcinomas (J:72391)
• 2.9% incidence of pancreatic adenocarcinomas (J:72391)
• 12% of heterozygous mutants developed carcinomas, which are rare in homozygotes (J:95318)
• 18% incidence of ear squamous cell carcinoma
• 57% of mutants exhibit sarcomas (J:17728)
• 56% incidence of sarcomas (J:72391)
• 2.9% incidence of undifferentiated sarcomas (J:72391)
• 56% of heterozygous mutants developed sarcomas (J:95318)
• 8.8% incidence (J:72391)
• 29% incidence (J:72391)
• 2.9% incidence of pancreatic adenocarcinomas

digestive/alimentary system
• 2.9% incidence of small intestinal polyps
• 2.9% incidence of stomach polyps

Mouse Models of Human Disease
OMIM ID Ref(s)
Li-Fraumeni Syndrome 1; LFS1 151623 J:17728

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.01
The Jackson Laboratory