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Phenotypes Associated with This Genotype
Genotype
MGI:2174782
Allelic
Composition
Trp53tm1Tyj/Trp53tm1Tyj
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (150 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• most lymphomas are thymic lymphomas (J:17728)
• 75% of observed tumors are thymic lymphomas (J:87501)

muscle

skeleton
• 13% incidence (J:72391)

mortality/aging
• most die by 6 months of age (J:17728)
• average life span 160 days (J:72391)
• 90% succumb to tumors and die by 7 months of age (J:87501)
• homozygous mutants die between ~50 to 250 days after birth (J:95318)
• 16.6% rather than the expected 25% of mutants are observed at weaning, indicating partial lethality either during embryogenesis or after birth but before weaning

neoplasm
• predominantly lymphomas with sarcomas and teratomas (J:17728)
• 71% of mice develop lymphoma, usually affecting the thymus (J:17728)
• 70% incidence (J:72391)
• 56% of homozygous nulls developed lymphomas (J:95318)
• most lymphomas are thymic lymphomas (J:17728)
• 75% of observed tumors are thymic lymphomas (J:87501)
• 3.3% incidence
• 3.3% incidence of stomach squamous cell carcinoma
• 50% incidence (J:72391)
• 40% of homozygous nulls developed sarcomas (J:95318)
• 20% incidence (J:72391)
• 13% incidence (J:72391)

cellular
• irradiated E13.5 heterozygous embryos showed no evidence of apoptosis in the hypothalamus compared to wildtype and heterozygotes that showed a high number of apoptotic cells
• MEFs initially did not show any significant differences in growth rate but by day 4, grew more rapidly than wildtype or heterozygous MEFs
• in mouse embryonic fibroblasts treated with UV irradiation

digestive/alimentary system
• 6.7% incidence
• 3.3% incidence of stomach polyps


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory