Phenotypes Associated with This Genotype

Genotype
MGI:2168563

• Allelic Composition: Cdh5^tm1Hub/Cdh5^tm1Hub
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cIco

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:54177 )

• death between E9.5 and E11.5

cardiovascular system

dilated dorsal aorta ( J:54177 )

• at E9.25, in the caudal part of the embryo the dorsal aorta is dilated

abnormal umbilical artery morphology ( J:54177 )

• at E9.25, in the caudal part of the embryo the umbilical artery is dilated

abnormal intersomitic vessel morphology ( J:54177 )

• at E9.25, limited angiogenic extensions (ie intersomitic vessels) are present

decreased angiogenesis ( J:54177 )

• at E9.25, limited angiogenic extensions (ie intersomitic vessels) are present and the head microcirculation is only partially developed

abnormal vasculogenesis ( J:54177 )

• at E8.5, embryonic vascularization is delayed with incomplete formation of the dorsal aortae in the caudal region, presence of the sinus venosus but absence of the posterior cardinal veins, and no PECAM staining rostral of the cardiac region; however vessel formation occurs in the caudal region

• at E8.5, endocardium is present but endothelial cells fail to form a lumen

• at E9.25, a vascular plexus is present but no organized large vessels are present

absent vitelline blood vessels ( J:54177 )

• endothelial cells along the vitello-embryonic stalk assemble into vesicles but do not form continuous vessels

• blood islands form and primary hematopoeisis is normal but failure of primary vascular plexus formation prevents normal blood circulation so that no primitive erythrocytes are seen in the embryo

distended pericardium ( J:54177 )

• at E10.5, distended pericardial cavity

irregular heartbeat ( J:54177 )

• at E10.5 the heart beat is irregular and weak

embryo

absent vitelline blood vessels ( J:54177 )

• endothelial cells along the vitello-embryonic stalk assemble into vesicles but do not form continuous vessels

• blood islands form and primary hematopoeisis is normal but failure of primary vascular plexus formation prevents normal blood circulation so that no primitive erythrocytes are seen in the embryo

incomplete embryo turning ( J:54177 )

• at E10.5

embryonic growth retardation ( J:54177 )

• at E10.5

incomplete somite formation ( J:54177 )

• at E10.5 there are never more than 20 somites compared to 35 in wild-type mice

abnormal umbilical cord blood vessel morphology ( J:54177 )

• at E9.25, umbilical vessels do not penetrate the allantois; however vascular organization of the placenta is normal

abnormal umbilical artery morphology ( J:54177 )

• at E9.25, in the caudal part of the embryo the umbilical artery is dilated

abnormal visceral yolk sac blood island morphology ( J:54177 )

• blood islands are concentrated in the placental hemisphere of the yolk sac with very few blood cells present in the embryonic hemisphere

cellular

abnormal cell death ( J:54177 )

• extensive cell death is seen beginning at E9.5

growth/size/body

embryonic growth retardation ( J:54177 )

• at E10.5

integument

pallor ( J:54177 )

• at E10.5