Analysis Tools
mortality/aging
|
• no offspring are produced from heterozygous matings
|
|
Allele Symbol Allele Name Allele ID |
Arid1bem1Iha endonuclease-mediated mutation 1, Izuho Hatada MGI:6286071 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• no offspring are produced from heterozygous matings
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• average body weight is lower at 10-13 weeks of age
• mice with hydrocephalus have reduced body weight relative to mutant mice without hydrocephalus
• however, mice exhibit normal body temperature
|
|
|
• in the cued test, the freezing time of mutants is increased without conditional stimulus on the day after conditioning and the tendency is maintained for 30 days
|
|
|
• in the open field test, mice exhibit reduced exploratory behaviors, including distance traveled and vertical activity, however time spend in the center area does not differ from wild-type mice
|
|
|
• in the Barnes maze, mutants exhibit a similar latency in reaching the target across acquisition sessions as wild-type mice, but in the probe trial 24 hours after the acquisition, mutants spend more time around the target hole than wild-type mice, suggesting normal spatial learning ability and improved memory
|
|
|
• in the Barns maze, mutants exhibit elevated perserveration, as indicated by a longer latency in reaching a target box in the opposite location during the reversal task
|
|
|
• in the elevated plus maze, mice show a lower number of entries into open and closed arms, a lower percentage of entries into open arms, spend less time in the open arms, and travel a lower total distance indicating increased anxiety-like behaviors
|
|
|
• exposure to intense stimuli such as electric foot shock or forced swim test induces larger locomotor responses than in wild-type mice
• in the contextual and cued fear conditioning test, mutants show less freezing during conditioning than wild-type mice, similar levels of freezing as wild-type mice in the context test, and more freezing in the altered context in the absence of a conditioned stimulus indicating an increase in fear generalization
|
|
|
• freezing time caused by conditional stimulus in the cued test 30 days after conditioning is longer suggesting enhanced long-term fear memory
|
|
|
• startle reflex responses caused by 110 dB stimuli are reduced
• however, startle responses caused by 120 dB are similar as in wild-type mice
|
|
|
• in the rotarod test, the latency of falling off the accelerating rotating rod is lower
• in the balance beam test, mice exhibit slower movement speed, longer duration of movement, and higher number of slips when crossing wide or narrow beams
• the number of movements is higher on the narrow beam and the latency of reaching the goal is larger on the wide beam
|
|
|
• grip strength and the length of falling off the wire mesh in the wire hang test are lower
|
|
|
• in the open field test, mice show stereotypic counts that possibly reflect repetitive behaviors
|
|
|
• in the hot-plate test, latency of paw responses to a nociceptive stimulus tend to be higher
|
|
|
• mice exhibit altered social behavior in the home cage, showing increased contact time with each other, however, overall activity levels are normal
• however, in a novel environment, mice exhibit normal social behavior in the social interaction test and the three-chamber test
|
|
|
• mice with hydrocephalus exhibit brains with a cavity with new vascularization
|
|
|
• mice with hydrocephalus exhibit brains with a cavity with new vascularization
|
|
|
• 5 of 9 mice exhibit severe hydrocephalus
|
|
|
• mice with hydrocephalus have enlarged lateral ventricle
|
|
|
• mice with hydrocephalus show corruption of the pyramidal cell layer of the hippocampus
|
|
|
• in response to a 110 dB stimulus, heterozygotes exhibit levels of prepulse inhibition (PPI) stimulus similar to wild-type littermates but at 120 dB, the PPI is lower than that of wild-type mice
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| autism spectrum disorder | DOID:0060041 | J:271850 | ||
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/30/2024 MGI 6.23 |
|
|
|
||