Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Daam1tm1.1Tpy mutation
(0 available);
any
Daam1 mutation
(77 available)
Gt(ROSA)26Sortm1Sor mutation
(8 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Nkx2-5tm1(cre)Rjs mutation
(1 available);
any
Nkx2-5 mutation
(21 available)
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muscle
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• in E13.5 embryos
• cardiomyocytes smaller, rounded and loosely attached to each other with thin cellular projections in conotruncal regions
• absent thick protrusions from leading edges of cardiomyocytes invading non-myocardial tissue
• cardiomyocytes randomly distributed and mixed with endocardial cells at bases of blood vessels
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cardiovascular system
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• in E13.5 embryos
• cardiomyocytes smaller, rounded and loosely attached to each other with thin cellular projections in conotruncal regions
• absent thick protrusions from leading edges of cardiomyocytes invading non-myocardial tissue
• cardiomyocytes randomly distributed and mixed with endocardial cells at bases of blood vessels
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Daam1tm1.1Tpy mutation
(0 available);
any
Daam1 mutation
(77 available)
Nkx2-5tm1(cre)Rjs mutation
(1 available);
any
Nkx2-5 mutation
(21 available)
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cardiovascular system
N |
• pulmonary artery and aorta in E16.5 embryos
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• in E16.5 embryos
• thicker ventricular trabecular zones, extending into lumen
• inconsistent size of right ventricular trabeculae
• irregular spacing of right ventricular trabeculae
• disorganized left ventricular trabeculae
• left ventricular trabeculae occupy much of ventricular lumen
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• in E16.5 embryos
• disorganized
• occupy much of lumen
• thicker trabecular zones
• thinner compact zones
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• in E16.5 embryos
• free wall does not extend as close to heart apex of 8-months old mice as in control mice
• base closer to tricuspid valve than in controls
• base not aligned with base of left ventricle
• thicker trabecular zones
• thinner compact zones
• inconsistent size of trabeculae
• irregular spacing of trabeculae
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• mean E/A ratio (flow velocity across mitral valve early in diastole divided by that late in diastole) in left ventricle of 2-months old mice is less than 1 in 8-months old mice, compared to greater than 1 in control mice
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• in 8-months old mice
• lower acceleration of pulmonary artery (PA) flow, indicating reduced RV contraction force
• reduced fractional shortening
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• lower acceleration of pulmonary artery (PA) flow in 8-months old mice
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muscle
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• disorganized left ventricular trabeculae
• in E16.5 embryos
• thicker ventricular trabecular zones, extending into lumen
• inconsistent size of right ventricular trabeculae
• irregular spacing of right ventricular trabeculae
• left ventricular trabeculae occupy much of ventricular lumen
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Daam1tm1.1Tpy mutation
(0 available);
any
Daam1 mutation
(77 available)
Daam2tm1Tpy mutation
(0 available);
any
Daam2 mutation
(49 available)
Nkx2-5tm1(cre)Rjs mutation
(1 available);
any
Nkx2-5 mutation
(21 available)
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cardiovascular system
N |
• compact layer width in E17.5 embryos
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• in 2-months old mice
• disturbed A-band marker Actc1 striation pattern
• nearly absent intermediate filament Desmin striation
• shorter A-bands
• Z-bands faint or absent
• no apparent I-bands, H-bands or M-lines
• intersecting and disorganized thick fibers in severely affected areas
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• lower-density material frequently observed between membranes of adjacent cardiomyocytes in 2-months old mice through electron microscopy
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• in E17.5 embryos
• failure of trabeculae to assimilate into compact zone, resulting in occluded ventricular lumens
• wider trabecular layers
• thicker individual trabeculae
• inter-trabecular spaces filled with detached endothelial cells
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• in 2-months old mice
• thicker walls and septa
• smaller lumen
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• in 2-months old mice
• thicker walls and septa
• smaller lumen
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• in 2-months old mice
• lower ejection fraction
• reduced fractional shortening
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• in 2-months old mice
• acceleration of pulmonary artery (PA) flow
• reduced fractional shortening
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• increased cardiomyocyte proliferation
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muscle
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• in 2-months old mice
• disturbed A-band marker Actc1 striation pattern
• nearly absent intermediate filament Desmin striation
• shorter A-bands
• Z-bands faint or absent
• no apparent I-bands, H-bands or M-lines
• intersecting and disorganized thick fibers in severely affected areas
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• lower-density material frequently observed between membranes of adjacent cardiomyocytes in 2-months old mice through electron microscopy
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• in E17.5 embryos
• failure of trabeculae to assimilate into compact zone, resulting in occluded ventricular lumens
• wider trabecular layers
• thicker individual trabeculae
• inter-trabecular spaces filled with detached endothelial cells
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• disturbed A-band marker Actc1 striation pattern and shorter A-bands in cardiomyocytes of 2-months old mice
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• no apparent H-bands in cardiomyocytes of 2-months old mice
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• no apparent M lines in cardiomyocytes of 2-months old mice
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• no apparent I-bands in cardiomyocytes of 2-months old mice
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• in cardiomyocytes of some 2-months old mice
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• in cardiomyocytes of some 2-months old mice
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cardiovascular system
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• right ventricle shifted anterior to left ventricle in E12.5 embryos
• AV cushion atop single ventricle connected to both atria in some embryos in E12.5 embryos
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• rudimentary in left ventricle of E16.5 embryos
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• rudimentary in left ventricle of E16.5 embryos
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• shorter than controls, not extended to the endocardial cushion in the atrioventricular canal in E12.5 embryos
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• mesenchyme-like organization of cardiomyocytes at ventricle base in E12.5 embryos
• right ventricle shifted anterior to left ventricle in E12.5 embryos
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mortality/aging
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• very few embryos seen at E16.5 and those that are, are mostly necrotic
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muscle
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• rudimentary in left ventricle of E16.5 embryos
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• rudimentary in left ventricle of E16.5 embryos
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cardiovascular system
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• thicker right ventricular trabecular zones, extending into lumen in E16.5 embryos
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• in right ventricle of E16.5 embryos
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muscle
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• thicker right ventricular trabecular zones, extending into lumen in E16.5 embryos
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• in right ventricle of E16.5 embryos
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