Analysis Tools
homeostasis/metabolism
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• mice injected with azoxymethane (AOM) followed by DSS administration show increased distal colorectal cancer compared to controls, with higher average tumor number and increased number of small tumors and proportion of high-grade tumors
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immune system
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• mice treated with dextran sodium sulfate (DSS) to induce colitis are protected from colitis-induced injury, showing suppression of weight loss and colonic shortening, decreased rectal bleeding rate, better epithelial crypt morphology, and higher proliferation rates and decreased cell death in colonic epithelial tissue compared to controls
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neoplasm
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• mice injected with azoxymethane (AOM) followed by DSS administration show increased distal colorectal cancer compared to controls, with higher average tumor number and increased number of small tumors and proportion of high-grade tumors
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digestive/alimentary system
| N |
• mice exhibit normal gastrointestinal development and do not show signs of spontaneous colorectal tumor development up to 8 months of age
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• mice treated with dextran sodium sulfate (DSS) to induce colitis are protected from colitis-induced injury, showing suppression of weight loss and colonic shortening, decreased rectal bleeding rate, better epithelial crypt morphology, and higher proliferation rates and decreased cell death in colonic epithelial tissue compared to controls
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