Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1tm1.1Qrm mutation
(0 available);
any
Nus1 mutation
(19 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation
(6 available);
any
Speer6-ps1 mutation
(4 available)
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homeostasis/metabolism
liver/biliary system
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• both total and free when fed Western diet
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr1h3tm1Djm mutation
(3 available);
any
Nr1h3 mutation
(32 available)
Nus1tm1.1Qrm mutation
(0 available);
any
Nus1 mutation
(19 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation
(6 available);
any
Speer6-ps1 mutation
(4 available)
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homeostasis/metabolism
liver/biliary system
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• both total and free when fed Western diet
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation
(3 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Nus1tm1.1Qrm mutation
(0 available);
any
Nus1 mutation
(19 available)
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homeostasis/metabolism
liver/biliary system
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1tm1.1Qrm mutation
(0 available);
any
Nus1 mutation
(19 available)
Tg(Cdh5-cre/ERT2)1Rha mutation
(3 available)
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cardiovascular system
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• E10.5 embryos from tamoxifen-treated mothers exhibit aberrant cerebral blood vessel pattering
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• E10.5 embryos from tamoxifen-treated mothers have dilated and disrupted organization of blood vessels
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embryo
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• E01.5 embryos are smaller in size when pregnant females are treated with tamoxifen at E8.5
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growth/size/body
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• E01.5 embryos are smaller in size when pregnant females are treated with tamoxifen at E8.5
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nervous system
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• E10.5 embryos from tamoxifen-treated mothers exhibit aberrant cerebral blood vessel pattering
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nus1tm1.1Qrm mutation
(0 available);
any
Nus1 mutation
(19 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
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mortality/aging
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• embryonic lethality at E10.5-E11.5
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growth/size/body
embryo
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• E10, but not E9, yolk sac shows aberrant blood vessel development
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cardiovascular system
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• cerebral blood vessels are truncated and exhibit disrupted organization instead of having a well-organized tree-like pattern
• cerebral blood vessels are highly dilated, being normal at E8.5 but becoming dilated by E9.5
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• cerebral blood vessels are truncated and exhibit disrupted organization instead of having a well-organized tree-like pattern
• the communicating artery is lost and disruption of major artery patterning is seen
• E10, but not E9, yolk sac shows aberrant blood vessel development
• however, no defect in cardiac development is seen and no obvious bronchial arch artery defects are seen
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• E10, but not E9, yolk sac shows aberrant blood vessel development
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nervous system
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• cerebral blood vessels are truncated and exhibit disrupted organization instead of having a well-organized tree-like pattern
• cerebral blood vessels are highly dilated, being normal at E8.5 but becoming dilated by E9.5
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