All Phenotypes Irs4<tm1.1Mfw> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Irs2^tm2Mfw/Irs2^tm2Mfw Irs4^tm1.1Mfw/Y Lepr^tm3(cre)Mgmj/Lepr⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5705239
cn2	Irs2^tm2Mfw/Irs2^tm2Mfw Irs4^tm1.1Mfw/Y Tg(Nes-cre)1Kln/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:5705238
ot3	Irs4^tm1.1Mfw/Y	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5705236

Allelic Composition	Irs2^tm2Mfw/Irs2^tm2Mfw Irs4^tm1.1Mfw/Y Lepr^tm3(cre)Mgmj/Lepr⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs2^tm2Mfw mutation (0 available); any Irs2 mutation (35 available)
Irs4^tm1.1Mfw mutation (0 available); any Irs4 mutation (5 available)
Lepr^tm3(cre)Mgmj mutation (1 available); any Lepr mutation (121 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:221293 )

N	• blood glucose levels are similar to controls

growth/size/body

growth/size/body region phenotype ( J:221293 )

N	• body weight is essentially similar to homozygous Irs2^tm2Mfw / heterozygous Lepr^tm3(cre)Mgmj male mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

increased body weight ( J:221293 )

• 60% heavier than controls

• 20% heavier than Irs2^tm2Mfw / Tg(Nes-cre)1Kln male mice

adipose tissue

abnormal adipose tissue amount ( J:221293 )

• increased adipose tissue relative to Irs2^tm2Mfw / Tg(Nes-cre)1Kln male mice

increased brown fat cell lipid droplet size ( J:221293 )

• larger lipid filled vacuoles in brown adipose tissue compared to Irs2^tm2Mfw / Tg(Nes-cre)1Kln male mice

• resembles white adipose tissue

liver/biliary system

hepatic steatosis ( J:221293 )

homeostasis/metabolism

increased circulating leptin level ( J:221293 )

• greatly elevated

decreased oxygen consumption ( J:221293 )

abnormal glucose homeostasis ( J:221293 )

increased circulating glucose level ( J:221293 )

• ad libitum feeding results in increased blood glucose

increased fasting circulating glucose level ( J:221293 )

• dramatically elevated at 3 months

increased circulating insulin level ( J:221293 )

• 5 fold elevation

impaired glucose tolerance ( J:221293 )

• dramatically impaired at 3 months

insulin resistance ( J:221293 )

• at 3 months and persisting to at least 9 months

decreased basal metabolism ( J:221293 )

• reduced heat production

behavior/neurological

increased food intake ( J:221293 )

• food intake increased 10% more than in Irs2^tm2Mfw / Tg(Nes-cre)1Kln male mice

Allelic Composition	Irs4^tm1.1Mfw/Y
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs4^tm1.1Mfw mutation (0 available); any Irs4 mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:221293 )

N	• normal leptin levels • normal fasted glucose levels at 3 months • normal glucose tolerance • normal insulin levels

increased circulating glucose level ( J:221293 )

• ad libitum feeding results in insignificantly increased blood glucose

growth/size/body

growth/size/body region phenotype ( J:221293 )

N	• normal size

mortality/aging

mortality/aging ( J:221293 )

N	• no embryonic lethality

reproductive system

reproductive system phenotype ( J:221293 )

N	• fertile (both sexes)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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