Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nmt2tm1.1Poru mutation
(0 available);
any
Nmt2 mutation
(30 available)
Tg(Lck-cre)1Cwi mutation
(3 available)
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immune system
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• moderate in the thymus
• however, numbers are normal in the blood, thymus and spleen
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• less so than in conditional Nmt1tm1.1Poru and Nmt2tm1.1Poru knock-out mice
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• CD4+ and CD8+ single positive cells
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hematopoietic system
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• moderate in the thymus
• however, numbers are normal in the blood, thymus and spleen
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• less so than in conditional Nmt1tm1.1Poru and Nmt2tm1.1Poru knock-out mice
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• CD4+ and CD8+ single positive cells
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nmt1tm1.1Poru mutation
(0 available);
any
Nmt1 mutation
(52 available)
Nmt2tm1.1Poru mutation
(0 available);
any
Nmt2 mutation
(30 available)
Tg(Lck-cre)1Cwi mutation
(3 available)
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immune system
N |
• mice do not exhibit any signs of autoimmune disease
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• during all stages of T cell development except DN1 that does not express the cre transgene
• 10-fold in double positive cells
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• following treatment with CpG-ODNs, mice fail to exhibit an increased in CD4+ and CD8+ single positive T cells compared with wild-type mice
• however, untreated mice exhibit normal T cell proliferation and treated mice do exhibit an increase in macrophages in the spleen and liver as in wild-type mice
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• when stimulated with IL2
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• however, cortical area is normal
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• in the thymus more so than single conditional knock-outs
• in the blood, lymph nodes and spleen as in Nmt1tm1.1Poru conditional knock-outs
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• at 2 and 6 months more so than in either single conditional knock-out
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• CD4+ and CD8+ single positive cells at 2 and 6 months
• following treatment with CpC-ODNs, mice fail to exhibit an increased in CD4+ and CD8+ single positive T cells compared with wild-type mice
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• CD4+ T cells isolated from the lymph nodes and spleen exhibit a shift from naive to activated/memory phenotypes
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• CD8+ T cells isolated from the lymph nodes and spleen exhibit a shift from naive to activated/memory phenotypes
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• in mice sensitized with D-galactosamine hydrochloride and treated with staphylococcal enterotoxin B
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• in mice sensitized with D-galactosamine hydrochloride and treated with staphylococcal enterotoxin B
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• in mice sensitized with D-galactosamine hydrochloride and treated with staphylococcal enterotoxin B
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• after TCR-independent activation
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• after TCR-independent activation
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• mice sensitized with D-galactosamine hydrochloride and treated with staphylococcal enterotoxin B exhibit reduced plasma levels of TNF, IL2 and IFN-gamma compared with wild-type mice
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homeostasis/metabolism
cellular
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• during all stages of T cell development except DN1 that does not express the cre transgene
• 10-fold in double positive cells
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• following treatment with CpG-ODNs, mice fail to exhibit an increased in CD4+ and CD8+ single positive T cells compared with wild-type mice
• however, untreated mice exhibit normal T cell proliferation and treated mice do exhibit an increase in macrophages in the spleen and liver as in wild-type mice
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• when stimulated with IL2
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endocrine/exocrine glands
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• however, cortical area is normal
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hematopoietic system
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• during all stages of T cell development except DN1 that does not express the cre transgene
• 10-fold in double positive cells
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• following treatment with CpG-ODNs, mice fail to exhibit an increased in CD4+ and CD8+ single positive T cells compared with wild-type mice
• however, untreated mice exhibit normal T cell proliferation and treated mice do exhibit an increase in macrophages in the spleen and liver as in wild-type mice
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• when stimulated with IL2
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• however, cortical area is normal
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• in the thymus more so than single conditional knock-outs
• in the blood, lymph nodes and spleen as in Nmt1tm1.1Poru conditional knock-outs
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• at 2 and 6 months more so than in either single conditional knock-out
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• CD4+ and CD8+ single positive cells at 2 and 6 months
• following treatment with CpC-ODNs, mice fail to exhibit an increased in CD4+ and CD8+ single positive T cells compared with wild-type mice
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• CD4+ T cells isolated from the lymph nodes and spleen exhibit a shift from naive to activated/memory phenotypes
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• CD8+ T cells isolated from the lymph nodes and spleen exhibit a shift from naive to activated/memory phenotypes
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