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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gipc1tm1.1Mhsi
targeted mutation 1.1, Michael Simons
MGI:5644333
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gipc1tm1.1Mhsi/Gipc1tm1.1Mhsi
Tg(Tek-cre)12Flv/? 		involves: 129S1/SvImJ * 129S4/SvJaeSor * C3H * C57BL/6 MGI:5696327
cn2
 		Gipc1tm1.1Mhsi/Gipc1tm1.1Mhsi
Tg(Cdh5-cre/ERT2)1Rha/? 		involves: 129S1/SvImJ * 129S4/SvJaeSor * C57BL/6 MGI:5696330
cn3
 		Gipc1tm1.1Mhsi/Gipc1tm1.1Mhsi
Tg(Myh11-cre,-EGFP)2Mik/? 		involves: 129S1/SvImJ * 129S4/SvJaeSor * C57BL/6 * DBA/2 MGI:5696325


Genotype
MGI:5696327
cn1
Allelic
Composition		 Gipc1tm1.1Mhsi/Gipc1tm1.1Mhsi
Tg(Tek-cre)12Flv/?
Genetic
Background		 involves: 129S1/SvImJ * 129S4/SvJaeSor * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gipc1tm1.1Mhsi mutation (1 available); any Gipc1 mutation (40 available)
Tg(Tek-cre)12Flv mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal systemic artery morphology ( J:221554 )
• less arterial branching and fewer collateral arteries in heart and kidney
• significant decrease in smaller arteries
• fewer arteriolar linkages in the spinotrapezius and a more dendritic arterial tree
• narrower input arterioles
coronary artery aneurysm ( J:221554 )
• aneurismal dilations in distal coronary arteries
abnormal blood circulation ( J:221554 )
• impaired recovery of blood flow after hind limb ischemia




Genotype
MGI:5696330
cn2
Allelic
Composition		 Gipc1tm1.1Mhsi/Gipc1tm1.1Mhsi
Tg(Cdh5-cre/ERT2)1Rha/?
Genetic
Background		 involves: 129S1/SvImJ * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gipc1tm1.1Mhsi mutation (1 available); any Gipc1 mutation (40 available)
Tg(Cdh5-cre/ERT2)1Rha mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal systemic artery morphology ( J:221554 )
• reduced number of collateral arteries
• reduced diameter of input arterioles in the spinotrapezius
abnormal blood circulation ( J:221554 )
• significant decline in blood flow recovery after hind limb ischemia




Genotype
MGI:5696325
cn3
Allelic
Composition		 Gipc1tm1.1Mhsi/Gipc1tm1.1Mhsi
Tg(Myh11-cre,-EGFP)2Mik/?
Genetic
Background		 involves: 129S1/SvImJ * 129S4/SvJaeSor * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gipc1tm1.1Mhsi mutation (1 available); any Gipc1 mutation (40 available)
Tg(Myh11-cre,-EGFP)2Mik mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
cardiovascular system phenotype ( J:221554 )
N
• normal arterial tree branching and collateral artery number in the heart and kidney
• normal spinotrapezius arterial tree
• blood flow recovery after hindlimb ischemia is similar to controls at 2 weeks
abnormal systemic artery morphology ( J:221554 )
• trend toward fewer small arteries in heart and kidney
• trend toward larger arterial size in hind limbs




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory