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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Trp53tm1Lejo
targeted mutation 1, Leisa Johnson
MGI:5641750
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Lejo/Trp53tm1Lejo 		involves: 129 MGI:5441551
cn2
 		Krastm4Tyj/Kras+
Trp53tm1Lejo/Trp53tm1Lejo 		involves: 129S4/SvJae MGI:5441555


Genotype
MGI:5441551
cn1
Allelic
Composition		 Rb1tm2Brn/Rb1tm2Brn
Trp53tm1Lejo/Trp53tm1Lejo
Genetic
Background		 involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2Brn mutation (3 available); any Rb1 mutation (107 available)
Trp53tm1Lejo mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:187012 )
• adenovirus-FLPe/IRES/Cre (Ad-FIC) induces a dose dependent increase in mortality with no mice surviving to 55 weeks post infection at concentrations greater than or equal to 5.00E+06 infectious units (iu)
• no mice survive to 40 weeks post infection when dosed with 5.00E+07 iu of Ad-FIC

neoplasm
increased lung small cell carcinoma incidence ( J:187012 )
• following infection with Ad-FIC
• early stage tumors are detected by 16 weeks post infection with Ad-FIC and late stage tumors are detected by about 32 weeks post infection

respiratory system
increased lung small cell carcinoma incidence ( J:187012 )
• following infection with Ad-FIC
• early stage tumors are detected by 16 weeks post infection with Ad-FIC and late stage tumors are detected by about 32 weeks post infection
abnormal lung morphology ( J:187012 )
• neuroendocrine hyperplasia is detected at 8 weeks post infection with Ad-FIC

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
lung small cell carcinoma DOID:5409 OMIM:182280
 J:187012




Genotype
MGI:5441555
cn2
Allelic
Composition		 Krastm4Tyj/Kras+
Trp53tm1Lejo/Trp53tm1Lejo
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Trp53tm1Lejo mutation (0 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased lung non-small cell carcinoma incidence ( J:187012 )
• following infection with adenovirus-FLPe/IRES/Cre (Ad-FIC)
increased lung adenocarcinoma incidence ( J:187012 )
• following infection with Ad-FIC

respiratory system
increased lung non-small cell carcinoma incidence ( J:187012 )
• following infection with adenovirus-FLPe/IRES/Cre (Ad-FIC)
increased lung adenocarcinoma incidence ( J:187012 )
• following infection with Ad-FIC

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
lung cancer DOID:1324 OMIM:211980
OMIM:608935
OMIM:612571
OMIM:612593
OMIM:614210
 J:187012




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory