Phenotypes associated with this allele

• Allele Symbol: Tg(tetO-Mir184)#Mnpy
• Allele Name: transgene insertion, Matthew N Poy
• Allele ID: MGI:5585169
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Ins2-rtTA)2Efr/0 Tg(tetO-Mir184)#Mnpy/0	involves: C57BL/6 * CBA	MGI:5585178
cx2	Lep^ob/Lep^ob Tg(Ins2-rtTA)2Efr/0 Tg(tetO-Mir184)#Mnpy/0	involves: C57BL/6 * CBA	MGI:5585179

Genotype
MGI:5585178

cx1

• Allelic Composition: Tg(Ins2-rtTA)2Efr/0; Tg(tetO-Mir184)#Mnpy/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

decreased pancreatic beta cell proliferation ( J:210552 )

• in doxycycline-treated mice

decreased pancreatic beta cell mass ( J:210552 )

• in doxycycline-treated mice

decreased pancreatic beta cell number ( J:210552 )

• in doxycycline-treated mice

homeostasis/metabolism

increased circulating glucose level ( J:210552 )

• in doxycycline-treated mice

decreased circulating insulin level ( J:210552 )

• in doxycycline-treated mice

impaired glucose tolerance ( J:210552 )

• in doxycycline-treated mice

cellular

decreased pancreatic beta cell proliferation ( J:210552 )

• in doxycycline-treated mice

Genotype
MGI:5585179

cx2

• Allelic Composition: Lep^ob/Lep^ob; Tg(Ins2-rtTA)2Efr/0; Tg(tetO-Mir184)#Mnpy/0
• Genetic Background: involves: C57BL/6 * CBA

homeostasis/metabolism

increased circulating glucose level ( J:210552 )

• in doxycycline-treated mice

decreased circulating insulin level ( J:210552 )

• in doxycycline-treated mice