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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(SV40-KLK7)1010Teg
transgene insertion 1010, Torbjorn Egelrud
MGI:5563691
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(SV40-KLK7)1010Teg/0 involves: C57BL/6J * CBA MGI:5563692


Genotype
MGI:5563692
tg1
Allelic
Composition
Tg(SV40-KLK7)1010Teg/0
Genetic
Background
involves: C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• from 5-6 weeks of age, mice show signs of itch with scratching, the frequency of which increases with time
• 73% of mice show signs of itch at 10-11 weeks of age, with varied frequency of scratching

growth/size/body
• 7-10% reduction in weight at 13-14 weeks of age

immune system
• at 3 weeks of age, skin shows a mild cellular inflammatory reaction with mixed leukocytes in the upper dermis
• increase in the number of mast cells in the dermis in some mice at 5 weeks of age
• leukocyte invasion of the epidermis is occasionally seen that then manifests as small groups of granulocytes within the thickened cornified layer, which is parakeratotic at these sites

integument
• at 3 weeks of age, skin shows a mild cellular inflammatory reaction with mixed leukocytes in the upper dermis
• increase in the number of mast cells in the dermis in some mice at 5 weeks of age
• leukocyte invasion of the epidermis is occasionally seen that then manifests as small groups of granulocytes within the thickened cornified layer, which is parakeratotic at these sites
• older mice exhibit a luster-less appearance of the coat
• macroscopic skin changes become apparent at 4-5 weeks of age, with loss of hair from a narrow zone around the eyes
• older mice show thinning of body hair in general
• at 3 weeks of age
• by 5 weeks of age, marked acanthosis-like hyperplasia and hyperkeratosis of the epidermis is seen
• at 3 weeks of age, skin shows mild to moderate epidermal hyperplasia
• increase in epidermal thickness at 7-8 weeks and 13-14 weeks of age
• increase in epithelial thickness of adnexal structures (hair follicle walls, and sebaceous glands and ducts)
• the skin surface on the back is covered in fine scales

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
atopic dermatitis DOID:3310 OMIM:603165
OMIM:PS603165
J:75714





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last database update
10/05/2021
MGI 6.17
The Jackson Laboratory