All Phenotypes Aldoc<tm1.1(KOMP)Vlcg> MGI Mouse

Phenotypes associated with this allele

Allelic Composition	Aldoc^{tm1.1(KOMP)Vlcg}/Aldoc^{tm1.1(KOMP)Vlcg}
Genetic Background	C57BL/6N-Aldoc^{tm1.1(KOMP)Vlcg}
Cell Lines	11975A-D3

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldoc^{tm1.1(KOMP)Vlcg} mutation (1 available); any Aldoc mutation (17 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating cholesterol level ( J:346664 )

• both male and female mice fed a chow diet show a significant reduction in plasma total cholesterol concentration relative to wild-type controls

• however, hepatic concentration of total cholesterol is relatively normal in both sexes

decreased circulating HDL cholesterol level ( J:346664 )

• both male and female mice fed a chow diet show a decrease in HDL-C levels relative to wild-type controls

decreased circulating triglyceride level ( J:346664 )

• female mice fed a chow diet show a significant reduction in plasma triglyceride concentration relative to wild-type controls

• however, male mice show no changes in plasma triglycerides and hepatic triglyceride concentrations are relatively normal in both sexes

increased circulating triglyceride level ( J:346664 )

• male mice treated with AAV8-TBG-Aldoc (to restore expression of Aldoc to hepatocytes), fasted for 24 h, and refed with a high carbohydrate diet for 16 h (to induce de novo lipogenesis within the liver) show a significant increase in plasma triglycerides

• however, treatment with AAV8-TBG-Aldoc has no effect on plasma triglyceride levels after only a 24-h fast

Allelic Composition	Aldoc^{tm1.1(KOMP)Vlcg}/Aldoc^{tm1.1(KOMP)Vlcg}
Genetic Background	C57BL/6N-Aldoc^{tm1.1(KOMP)Vlcg}/MbpMmucd
Cell Lines	11975A-D3

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldoc^{tm1.1(KOMP)Vlcg} mutation (1 available); any Aldoc mutation (17 available)

Data Sources

IMPC Data for Aldoc

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

respiratory system

increased pulmonary respiratory rate ( J:211773 )

IMPC - TCP

decreased pulmonary ventilation ( J:211773 )

IMPC - TCP

Allelic Composition	Aldoc^{tm1.1(KOMP)Vlcg}/Aldoc^{tm1.1(KOMP)Vlcg}
Genetic Background	C57BL/6N-Aldoc^{tm1.1(KOMP)Vlcg}/Ucd
Cell Lines	11975A-D3

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aldoc^{tm1.1(KOMP)Vlcg} mutation (1 available); any Aldoc mutation (17 available)

Data Sources

IMPC Data for Aldoc

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

hyperactivity ( J:211773 )

IMPC - UCD

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - UCD

renal/urinary system

abnormal kidney morphology ( J:211773 )

IMPC - UCD

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:346664 )

• male mice fed a chow diet show a significant decrease in body weight relative to single Ldlr^tm1Her homozygotes

• however, female body weight is similar to that in single Ldlr^tm1Her homozygotes

homeostasis/metabolism

decreased circulating cholesterol level ( J:346664 )

• both male and female mice fed a chow diet show a significant reduction in plasma total cholesterol concentration relative to single Ldlr^tm1Her homozygotes

decreased circulating LDL cholesterol level ( J:346664 )

• both male and female mice fed a standard chow diet show a decreased plasma cholesterol concentration within LDL fractions

• however, the amount of circulating LDL particles is similar to that in single Ldlr^tm1Her homozygotes in both sexes, as measured by ApoB protein abundance at the apex of the LDL-C peak and within the triglyceride-rich lipoproteins

decreased circulating triglyceride level ( J:346664 )

• male mice fed a chow diet show a significant reduction in plasma triglyceride concentration relative to single Ldlr^tm1Her homozygotes

• however, female plasma triglyceride levels are not significantly different from those in single Ldlr^tm1Her homozygotes

decreased liver cholesterol level ( J:346664 )

• both male and female mice fed a chow diet show a significant reduction in liver total cholesterol concentration relative to single Ldlr^tm1Her homozygotes

decreased liver triglyceride level ( J:346664 )

• both male and female mice fed a chow diet show a significant reduction in liver triglyceride concentration relative to single Ldlr^tm1Her homozygotes

liver/biliary system

decreased liver cholesterol level ( J:346664 )

• both male and female mice fed a chow diet show a significant reduction in liver total cholesterol concentration relative to single Ldlr^tm1Her homozygotes

decreased liver triglyceride level ( J:346664 )

• both male and female mice fed a chow diet show a significant reduction in liver triglyceride concentration relative to single Ldlr^tm1Her homozygotes

decreased liver weight ( J:346664 )

• male mice fed a chow diet show a significant decrease in liver weight relative to single Ldlr^tm1Her homozygotes

• however, liver weight to body weight ratio is unaffected in males, and no differences in liver weight or liver weight to body weight ratio are observed in female mice relative to single Ldlr^tm1Her homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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