Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnao1tm2Rneu mutation
(0 available);
any
Gnao1 mutation
(29 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnao1tm2Rneu mutation
(0 available);
any
Gnao1 mutation
(29 available)
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behavior/neurological
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• both males and females show reduced activity in the first 10 min of the open field arena indicating decreased activity in a novel environment
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• females exhibit a reduced retention time on the accelerating rotarod, while males are unaffected
• however, mice do not show a difference in learning rate on the rotarod
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• females, but not males, show reduced forepaw grip strength
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• females exhibit abnormal gait with reduced stride length and increased paw angle variability while males only show increased paw angle variability
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• females show reduced stride length
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• mice exhibit reduced activity in the open field arena, with both males and females showing reduced activity in the first 10 minutes (novel environment), and females, but not males, showing reduced activity in the next 10-30 min designated as sustained activity
• both males and females show reduced total activity
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Allelic
Composition |
Gnao1tm2Rneu/Gnao1+
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Genetic
Background |
involves: 129S1/Sv * C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gnao1tm2Rneu mutation
(0 available);
any
Gnao1 mutation
(29 available)
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behavior/neurological
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• mice treated with epinephrine exhibit enhanced reduction in burst frequency of induced epileptiform activity compared with control mice
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nervous system
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• mice treated with epinephrine exhibit enhanced reduction in burst frequency of induced epileptiform activity compared with control mice
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Analysis Tools