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Allele Symbol Allele Name Allele ID |
Cdc42tm1.1Rac targeted mutation 1.1, Richard A Cerione MGI:5495277 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die within 72 hours of birth
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• more than half of mice exhibit mild or moderate hemorrhage in the lateral ventricle of the brain
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• at E14.5, only sporadic proliferating cells are located in the basal ventricular zone and subventricular zone compared with wild-type mice
• at E16.5, proliferating cells are displaced from the ventricular surface and are present randomly in the basal ventricular and subventricular zone compared with wild-type mice
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• decreased cell number at E16.5
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• decreased cell number at E16.5
• nuclei lose their apical-basal direction
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• clustering of the ependymal cells
• lack of lining ependymal cells inside the third ventricle, aqueduct and spinal cord central canal
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• bilateral
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• more than half of mice exhibit mild or moderate hemorrhage in the lateral ventricle of the brain
• neuronal cells lining the lateral ventricle lack apical membrane domain
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• lack of lining ependymal cells
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• lack of lining ependymal cells
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• slight increase in cell numbers with disruption of cell polarization at E14.5
• flattened surface with hypoplasia
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• abnormal orientation at E16.5 indicating a folding problem
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• lacking ventricular and sub-ventricular zones
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• slightly
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• E18.5 glial cells exhibit a fried egg morphology in culture unlike wild-type cells
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• decreased apical neuronal progenitor cell numbers in the cerebral cortex at E14.5 and E16.5
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• collapse of the central canal and lack of differentiated ependymal cells
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• at E14.5 and E16.5, radial glial cell nuclei exhibit impaired interkinetic nuclear migration compared to in wild-type cells
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• at E14.5, only sporadic proliferating cells are located in the basal ventricular zone and subventricular zone compared with wild-type mice
• at E16.5, proliferating cells are displaced from the ventricular surface and are present randomly in the basal ventricular and subventricular zone compared with wild-type mice
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• in neonates
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• more than half of mice exhibit mild or moderate hemorrhage in the lateral ventricle of the brain
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• in neonates
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• more than half of mice die before 3 months of age due to severe hydrocephalus
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• severe
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• ependymal cells are detached from the lateral and third ventricle
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• ependymal cells are detached from the lateral and third ventricle
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• in most mice at 4 weeks
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• in most mice at 4 weeks
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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