Phenotypes associated with this allele
hematopoietic system
|
• reduced bone marrow cellularity
|
|
• white blood cell counts are significantly reduced after tamoxifen treatment
|
|
• reduced numbers of CD150+ CD480- LIN- SCA1+ cKIT+ stem cells
|
immune system
|
• white blood cell counts are significantly reduced after tamoxifen treatment
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Sjm mutation
(1 available);
any
Cxcl12 mutation
(24 available)
Tg(Tek-cre)12Flv mutation
(1 available)
|
|
|
hematopoietic system
|
• reduced effectiveness in donor cell reconstitution
|
hematopoietic system
|
• increased hematopoietic cells and colony forming cells in the blood and spleen
|
hematopoietic system
N |
• normal cellularity and hematopoietic stem cell frequency
• bone marrow/spleen lineage composition is normal
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Sjm mutation
(1 available);
any
Cxcl12 mutation
(24 available)
Tg(Col1a1-cre)2Bek mutation
(1 available)
|
|
|
hematopoietic system
|
• reduced CLP and IL7RalphaLMPP cells
|
|
• effectiveness of donor reconstitution of T and B cells is reduced
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Sjm mutation
(1 available);
any
Cxcl12 mutation
(24 available)
Tg(Nes-cre)1Kln mutation
(4 available)
|
|
|
hematopoietic system
N |
• hematopoietic stem cells and hematopoietic lineage composition are both normal
• bone marrow/spleen cellularity is normal
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcl12tm1.1Sjm mutation
(1 available);
any
Cxcl12 mutation
(24 available)
Tg(Prrx1-cre)1Cjt mutation
(2 available)
|
|
|
hematopoietic system
|
• fewer B lineage progenitors
|
|
• significant reduction in bone marrow cellularity
• reduced frequency of hematopoietic stem cells, CLP and IL7RalphaLMPP cells
|
immune system
|
• fewer B lineage progenitors
|