Analysis Tools
immune system
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• mice fed a Western diet exhibit a higher degree of inflammation in epididymal fat than controls on the same diet
• Western diet-fed mice treated with antibiotic show decreased adipose tissue inflammation
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• cultured cochleae stimulated with LPS pulsed with ATP do not secrete IL-1beta like in wild-type cochlea
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adipose tissue
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• mice fed a Western diet exhibit a greater increase in body fat mass than controls on the same diet
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• mice fed a Western diet exhibit a higher degree of inflammation in epididymal fat than controls on the same diet
• Western diet-fed mice treated with antibiotic show decreased adipose tissue inflammation
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cellular
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• mice fed a Western diet exhibit increased ROS production, indicating increased oxidative stress
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digestive/alimentary system
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• mice fed a Western diet show a higher increase in bacterial growth of mesenteric lymph node cultures, indicating increased bacterial translocation through the gut barrier and impaired gut barrier
• Western diet-fed mice treated with antibiotic show lowered bacterial growth in cultured lymph nodes, indicating reduced bacterial translocation
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• mice fed a Western diet show a greater gut microbiota dysbiosis than controls on the same diet
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growth/size/body
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• mice fed a Western diet exhibit a greater increase in body fat mass than controls on the same diet
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• mice fed a Western diet (high-fat with fructose in the drinking water) gain more weight than controls on the same diet, despite a progressive reduction in the caloric intake/body weight ratio
• Western diet-fed mice treated with antibiotic exhibit reduced weight gain
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• mice fed a Western diet show increased liver-to-body weight ratio
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homeostasis/metabolism
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• mice fed a Western diet show reduced total energy expenditure
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• mice fed a Western diet (high-fat with fructose in the drinking water) gain more weight than controls on the same diet, despite a progressive reduction in the caloric intake/body weight ratio
• Western diet-fed mice treated with antibiotic exhibit reduced weight gain
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• liver triglyceride levels are increased in mice fed a Western diet
• Western die-fed mice treated with antibiotic show decreased hepatic triglyceride accumulation
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• mice fed a Western diet exhibit a higher hepatic lipid uptake
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liver/biliary system
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• mice fed a Western diet exhibit more severe liver injury than controls, showing increased expression of TLR4, TLR5, and TLR9, F4/80, MCP-1, and type I collagen
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• mice fed a Western diet show increased liver-to-body weight ratio
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• liver triglyceride levels are increased in mice fed a Western diet
• Western die-fed mice treated with antibiotic show decreased hepatic triglyceride accumulation
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• mice fed a Western diet show higher levels of micro and macrovesicular steatosis than controls
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| metabolic dysfunction-associated steatotic liver disease | DOID:0080208 |
OMIM:613282 OMIM:613387 |
J:256504 | |
