Phenotypes associated with this allele

• Allele Symbol: Ak8^{Gt(OST16378)Lex}
• Allele Name: gene trap OST16378, Lexicon Genetics
• Allele ID: MGI:5429197
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ak8^Gt(OST16378)Lex/Ak8^Gt(OST16378)Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:5429555

Genotype
MGI:5429555

hm1

• Allelic Composition: Ak8^{Gt(OST16378)Lex}/Ak8^{Gt(OST16378)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:185566 )

N • no notable behavior phenotype despite hydrocephalus

craniofacial

craniofacial phenotype ( J:185566 )

N • doming of head not observed

growth/size/body

growth/size/body region phenotype ( J:185566 )

N • situs inversus was not observed

nervous system

hydrocephaly ( J:185566 )

• mild to moderate hydrocephalus that becomes evident at approximately 2 weeks of age (late onset) and reaches maximum severity by 3 weeks of age

dilated lateral ventricle ( J:185566 )

• mild bilateral dilation of lateral ventricles

small hippocampus ( J:185566 )

• reduced size of hippocampus

reproductive system

reproductive system phenotype ( J:185566 )

N • normal fertility

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hydrocephalus		DOID:10908	OMIM:123155 OMIM:236600 OMIM:236635 OMIM:307000 OMIM:615219	J:185566