About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fbn1tm3.2Lysa
targeted mutation 3.2, Lynn Y Sakai
MGI:5313375
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fbn1tm3.2Lysa/Fbn1tm3.2Lysa Not Specified MGI:5313383
ht2
Fbn1tm3.2Lysa/Fbn1+ Not Specified MGI:5313384


Genotype
MGI:5313383
hm1
Allelic
Composition
Fbn1tm3.2Lysa/Fbn1tm3.2Lysa
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1tm3.2Lysa mutation (0 available); any Fbn1 mutation (171 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Thick skin in Fbn1tm3.2Lysa/Fbn1+ and Fbn1tm3.2Lysa/Fbn1tm3.2Lysa mice

integument
• mice exhibit thickened and less elastic skin compared to in wild-type mice
• excessive collagen deposition
• persisting through old age

limbs/digits/tail
• short proximal and distal phalanges in the fore and hind paws at 3 to 4 weeks of age
• at 1 month of age
• at 1 month of age
• at 1 month of age
• at 3 to 4 weeks of age

adipose tissue

cardiovascular system
N
• in contrast to Fbn1-targeted mouse models of Marfan Syndrome, aortic root morphology is normal

skeleton
• at 3 to 4 weeks of age
• short proximal and distal phalanges in the fore and hind paws at 3 to 4 weeks of age
• at 1 month of age
• at 1 month of age
• at 1 month of age
• at 3 to 4 weeks of age




Genotype
MGI:5313384
ht2
Allelic
Composition
Fbn1tm3.2Lysa/Fbn1+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1tm3.2Lysa mutation (0 available); any Fbn1 mutation (171 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Thick skin in Fbn1tm3.2Lysa/Fbn1+ and Fbn1tm3.2Lysa/Fbn1tm3.2Lysa mice

integument
• mice exhibit thickened and less elastic skin compared to in wild-type mice
• excessive collagen deposition
• persisting through old age

limbs/digits/tail
• short proximal and distal phalanges in the fore and hind paws at 3 to 4 weeks of age
• at 3 to 4 weeks of age

adipose tissue

cardiovascular system
N
• in contrast to Fbn1-targeted mouse models of Marfan Syndrome, aortic root morphology is normal

skeleton
• short proximal and distal phalanges in the fore and hind paws at 3 to 4 weeks of age
• at 3 to 4 weeks of age





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory