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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fbn1tm3.2Lysa
targeted mutation 3.2, Lynn Y Sakai
MGI:5313375
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fbn1tm3.2Lysa/Fbn1tm3.2Lysa Not Specified MGI:5313383
ht2
Fbn1tm3.2Lysa/Fbn1+ Not Specified MGI:5313384


Genotype
MGI:5313383
hm1
Allelic
Composition
Fbn1tm3.2Lysa/Fbn1tm3.2Lysa
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1tm3.2Lysa mutation (0 available); any Fbn1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Thick skin in Fbn1tm3.2Lysa/Fbn1+ and Fbn1tm3.2Lysa/Fbn1tm3.2Lysa mice

integument
• mice exhibit thickened and less elastic skin compared to in wild-type mice
• excessive collagen deposition
• persisting through old age

limbs/digits/tail
• short proximal and distal phalanges in the fore and hind paws at 3 to 4 weeks of age
• at 1 month of age
• at 1 month of age
• at 1 month of age
• at 3 to 4 weeks of age

adipose tissue

cardiovascular system
N
• in contrast to Fbn1-targeted mouse models of Marfan Syndrome, aortic root morphology is normal

skeleton
• at 3 to 4 weeks of age
• short proximal and distal phalanges in the fore and hind paws at 3 to 4 weeks of age
• at 1 month of age
• at 1 month of age
• at 1 month of age
• at 3 to 4 weeks of age




Genotype
MGI:5313384
ht2
Allelic
Composition
Fbn1tm3.2Lysa/Fbn1+
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn1tm3.2Lysa mutation (0 available); any Fbn1 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Thick skin in Fbn1tm3.2Lysa/Fbn1+ and Fbn1tm3.2Lysa/Fbn1tm3.2Lysa mice

integument
• mice exhibit thickened and less elastic skin compared to in wild-type mice
• excessive collagen deposition
• persisting through old age

limbs/digits/tail
• short proximal and distal phalanges in the fore and hind paws at 3 to 4 weeks of age
• at 3 to 4 weeks of age

adipose tissue

cardiovascular system
N
• in contrast to Fbn1-targeted mouse models of Marfan Syndrome, aortic root morphology is normal

skeleton
• short proximal and distal phalanges in the fore and hind paws at 3 to 4 weeks of age
• at 3 to 4 weeks of age





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
07/09/2019
MGI 6.14
The Jackson Laboratory